庆大霉素发酵中共同产生的氨基糖苷类抗生素Sch 14342的生物活性
Biological activity of Sch 14342, an aminoglycoside antibiotic coproduced in the gentamicin fermentation.
作者信息
Waitz J A, Moss E L, Oden E M, Wagman G H, Weinstein M J
出版信息
Antimicrob Agents Chemother. 1972 Dec;2(6):464-9. doi: 10.1128/AAC.2.6.464.
Sch 14342 is an aminoglycoside antibiotic coproduced as a minor component in the gentamicin fermentation. Sch 14342 was found to have the same antibacterial spectrum as gentamicin in vitro and in vivo, and was approximately one-third as active in mouse protection tests. Sch 14342 relative to gentamicin was one-third as toxic in acute tests in mice, one-eighth as toxic in renal toxicity tests in dogs, and an estimated one-tenth as toxic in cat ataxia tests. Sch 14342 possesses a significantly improved therapeutic index relative to gentamicin with reference to ataxia potential and renal toxicity.
Sch 14342是庆大霉素发酵过程中作为次要成分共同产生的一种氨基糖苷类抗生素。研究发现，Sch 14342在体外和体内具有与庆大霉素相同的抗菌谱，在小鼠保护试验中的活性约为庆大霉素的三分之一。相对于庆大霉素，Sch 14342在小鼠急性试验中的毒性为其三分之一，在犬类肾毒性试验中的毒性为其八分之一，在猫共济失调试验中的毒性估计为其十分之一。相对于庆大霉素，Sch 14342在共济失调可能性和肾毒性方面具有显著改善的治疗指数。
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