新氨基糖苷类抗生素奈替米星与庆大霉素的抗菌活性比较。
Antibacterial activity of netilmicin, a new aminoglycoside antibiotic, compared with that of gentamicin.
作者信息
Phillips I, Smith A, Shannon K
出版信息
Antimicrob Agents Chemother. 1977 Mar;11(3):402-6. doi: 10.1128/AAC.11.3.402.
Abstract
The antibacterial activity of netilmicin (Sch 20569), a new semisynthetic aminoglycoside, was compared with that of gentamicin against a variety of gram-negative bacteria, staphylococci, and streptococci. Both antibiotics had similar activity against most organisms, but netilmicin had appreciably greater activity against gram-negative organisms that were resistant to gentamicin because these species synthesized aminoglycoside 3-N-acetyltransferase I or aminoglycoside 2''-O-nucleotidyltransferase. Netilmicin was also more active than gentamicin against gentamicin-resistant strains of Staphylococcus aureus that produced two enzymes-aminoglycoside-2''-O-phosphotransferase and aminoglycoside-6'-N-acetyltransferase.
摘要
新的半合成氨基糖苷类药物奈替米星（Sch 20569）的抗菌活性与庆大霉素针对多种革兰氏阴性菌、葡萄球菌和链球菌的抗菌活性进行了比较。两种抗生素对大多数微生物的活性相似，但奈替米星对耐庆大霉素的革兰氏阴性菌具有明显更强的活性，因为这些菌种合成了氨基糖苷3 - N - 乙酰转移酶I或氨基糖苷2'' - O - 核苷酸转移酶。奈替米星对产生两种酶——氨基糖苷 - 2'' - O - 磷酸转移酶和氨基糖苷 - 6' - N - 乙酰转移酶的耐庆大霉素金黄色葡萄球菌菌株也比庆大霉素更具活性。
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Antibacterial activity of netilmicin, a new aminoglycoside antibiotic, compared with that of gentamicin.新氨基糖苷类抗生素奈替米星与庆大霉素的抗菌活性比较。
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