烷基酰胺和胺类的化学结构与抗菌活性的关系
Relationship of chemical structure and antimicrobial activity of alkyl amides and amines.
作者信息
Kabara J J, Conley A J, Truant J P
出版信息
Antimicrob Agents Chemother. 1972 Dec;2(6):492-8. doi: 10.1128/AAC.2.6.492.
Abstract
Contrary to the limited effects of alkyl amides and their corresponding N-derivatives, alkyl amines affected both gram-positive and gram-negative organisms. As with other alkyl derivatives the most sensitive gram-negative bacteria were usually more resistant than the most resistant gram-positive bacteria. Compounds with a chain-length of 11 to 15 are most active. Although some of the general properties relating the activity of fatty acids to their antimicrobial action are similar to those of amine compounds, the amines are unique in that monounsaturation does not increase compound activity. The possible modes of action of these compounds are discussed.
摘要
与烷基酰胺及其相应的 N-衍生物的有限作用相反，烷基胺对革兰氏阳性菌和革兰氏阴性菌均有影响。与其他烷基衍生物一样，最敏感的革兰氏阴性菌通常比最具抗性的革兰氏阳性菌更具抗性。链长为 11 至 15 的化合物活性最高。尽管一些将脂肪酸活性与其抗菌作用相关联的一般特性与胺类化合物相似，但胺类化合物的独特之处在于单不饱和性不会增加化合物的活性。文中讨论了这些化合物可能的作用方式。
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