Borders D B, Kirby J P, Wetzel E R, Davies M C, Hausmann W K
Antimicrob Agents Chemother. 1972 May;1(5):403-7. doi: 10.1128/AAC.1.5.403.
An analytical procedure was devised which can distinguish members of the streptothricin family of antibiotics. It is based upon an analysis of the hydrolysis products of the antibiotics using a Technicon amino acid autoanalyzer under special conditions. The various fragments including the different streptolidine-amino sugar compounds were well resolved. A basic water-soluble antibiotic discovered in our laboratories and named LL-BL136 was compared to other members of this group by this technique. It was not differentiated from the antibiotic SF-701 reported by Tsuruoka. The autoanalyzer results along with other physicochemical data permitted a structure proposal for this antibiotic, which is the N-methyl-desformimino derivative of antibiotic LL-AC541.
设计了一种分析方法，可区分链丝菌素类抗生素的成员。该方法基于在特殊条件下使用Technicon氨基酸自动分析仪对抗生素水解产物进行分析。包括不同链霉胍 - 氨基糖化合物在内的各种片段得到了很好的分离。通过该技术，将我们实验室发现的一种碱性水溶性抗生素LL-BL136与该组中的其他成员进行了比较。它与鹤冈报道的抗生素SF-701没有区别。自动分析仪的结果以及其他物理化学数据为这种抗生素提出了一种结构推测，即抗生素LL-AC541的N-甲基-去甲脒基衍生物。
