抗生素LL-AC541的分离与特性分析

Isolation and characterization of antibiotic LL-AC541.

作者信息

Zbinovsky V, Hausmann W K, Wetzel E R, Borders D B, Patterson E L

出版信息

Appl Microbiol. 1968 Apr;16(4):614-6. doi: 10.1128/am.16.4.614-616.1968.

DOI:10.1128/am.16.4.614-616.1968

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC547479/

Abstract

A new basic, water-soluble antibiotic designated LL-AC541, produced by a strain of Streptomyces hygroscopicus (NRRL 3111), was isolated as a hydrochloride salt; alpha (25), - 58 degrees , melting point, 200 to 215 C (decomposition). It is structurally related to streptothricin but does not contain beta-lysine. Isolation procedures, physicochemical properties, antimicrobial spectrum, and in vivo testing results are presented. Another very closely related antibiotic obtained from the same fermentation is briefly described.

摘要

一种由吸水链霉菌菌株（NRRL 3111）产生的新型碱性水溶性抗生素LL - AC541，被分离为盐酸盐；α（25）， - 58度，熔点200至215℃（分解）。它在结构上与链丝菌素相关，但不含β - 赖氨酸。文中介绍了其分离程序、理化性质、抗菌谱和体内测试结果。还简要描述了从同一发酵过程中获得的另一种密切相关的抗生素。

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本文引用的文献

1

Partial structure of antibiotic LL-AC541.抗生素LL-AC541的部分结构。

Tetrahedron Lett. 1967 Oct;42:4187-92. doi: 10.1016/s0040-4039(01)89719-7.

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