Northrup R S, Doyle M A, Feeley J C
Antimicrob Agents Chemother. 1972 Apr;1(4):310-4. doi: 10.1128/AAC.1.4.310.
Trimethoprim and sulfamethoxazole were tested individually and in combination against El Tor and classical biotype strains of Vibrio cholerae. Determinations of the minimal inhibitory concentration in liquid media and by an agardilution method showed that classical strains were uniformly more resistant to sulfamethoxazole than were El Tor strains. In agar-dilution studies, trimethoprim was equally active against both biotypes. Combination of the agents produced a synergistic action against all strains tested. Testing for susceptibility to sulfonamide is suggested as a possible method for differentiating between El Tor and classical biotypes of V. cholerae.
分别对甲氧苄啶和磺胺甲恶唑以及它们的组合进行了针对霍乱弧菌埃尔托生物型和古典生物型菌株的测试。通过液体培养基和琼脂稀释法测定最低抑菌浓度表明,古典生物型菌株对磺胺甲恶唑的耐药性普遍高于埃尔托生物型菌株。在琼脂稀释研究中,甲氧苄啶对两种生物型的活性相同。这两种药物的组合对所有测试菌株产生了协同作用。建议将磺胺类药物敏感性测试作为区分霍乱弧菌埃尔托生物型和古典生物型的一种可能方法。