Rose A G
Thorax. 1972 Jul;27(4):401-9. doi: 10.1136/thx.27.4.401.
The mitral valve was replaced by a pig aortic valve in 33 patients at Groote Schuur Hospital. Eleven of the failed heterograft aortic valves were examined at intervals of from 2 to 32 months after insertion. Fourteen control pig aortic valves were also examined. Electron microscopy was performed on two of the failed heterograft valves and three control pig valves. Failure of the heterograft was due to stretching and deformation of the cusps with resultant valvular incompetence. Stretching of the cusp was a result of reduction in the amount of its collagen content. The elastic tissue appeared little altered. A microscopic layer of fibrin thrombus was present on the surface of 8 of the 11 valves. Only 2 of the 11 valves showed invasion of the graft by immunologically competent cells. No valve showed any sign of infection or calcification. The denatured collagen of the heterograft has a low antigenicity and also, infortunately, a limited durability.
在格罗特·舒尔医院，33例患者的二尖瓣被猪主动脉瓣替代。对11个失效的异种移植主动脉瓣在植入后2至32个月的间隔时间内进行了检查。还检查了14个对照猪主动脉瓣。对2个失效的异种移植瓣膜和3个对照猪瓣膜进行了电子显微镜检查。异种移植瓣膜失效是由于瓣叶拉伸和变形，导致瓣膜功能不全。瓣叶拉伸是其胶原蛋白含量减少的结果。弹性组织变化不大。11个瓣膜中有8个表面存在一层微观纤维蛋白血栓。11个瓣膜中只有2个显示有免疫活性细胞侵入移植物。没有瓣膜显示出任何感染或钙化迹象。异种移植物的变性胶原蛋白抗原性低，不幸的是，耐久性也有限。
