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记忆痕迹:通过环己酰亚胺和电惊厥休克进行实验性分离

Memory traces: experimental separation by cycloheximide and electroconvulsive shock.

作者信息

Andry D K, Luttges M W

出版信息

Science. 1972 Nov 3;178(4060):518-20. doi: 10.1126/science.178.4060.518.

DOI:10.1126/science.178.4060.518
PMID:4673046
Abstract

Mice given cycloheximide or saline were trained with a single trial. Electroconvulsive shock was administered to both groups at various times after training. Cycloheximide led to memory that decayed with time. Cycloheximide plus electroconvulsive shock produced complete amnesia at times when neither treatment alone produced amnesia. Only two types of processes appear to support memory storage in our study.

摘要

给小鼠注射放线菌酮或生理盐水后进行单次训练。训练后的不同时间对两组小鼠施加电惊厥休克。放线菌酮导致记忆随时间衰退。在单独一种治疗均未产生失忆的时间点,放线菌酮加电惊厥休克会导致完全失忆。在我们的研究中,似乎只有两种过程支持记忆存储。

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Role of RNA and protein in memory storage: a review.RNA与蛋白质在记忆存储中的作用:综述
Behav Genet. 1974 Mar;4(1):29-81. doi: 10.1007/BF01066705.
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