Schlesinger K, Lipsitz D U, Peck P L, Pelleymounter M A, Stewart J M, Chase T N
Behav Neural Biol. 1983 Sep;39(1):30-9. doi: 10.1016/s0163-1047(83)90586-1.
Subcutaneous post-trial administration of the neuropeptide substance P was found to reverse the amnestic effects of both electroconvulsive shock and cycloheximide. Substance P was observed to reverse the amnestic effects of cycloheximide in both C57B1/6J and heterogeneous strain (HS) mice. Substance P was found to reverse the amnestic effects of electroconvulsive seizures in C57B1/6J animals. Peripheral injections of substance P were also found to facilitate the retention of a single-trial passive avoidance habit in animals of both genotypes, provided a weak footshock was used during training.
研究发现，在试验后皮下注射神经肽P物质可逆转电惊厥休克和环己酰亚胺的遗忘效应。在C57B1/6J小鼠和异质品系（HS）小鼠中均观察到P物质可逆转环己酰亚胺的遗忘效应。在C57B1/6J动物中发现P物质可逆转电惊厥发作的遗忘效应。还发现，外周注射P物质可促进两种基因型动物对单次被动回避习惯的记忆，前提是在训练期间使用较弱的足部电击。
