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Biochem J. 1972 Jun;128(1):41-6. doi: 10.1042/bj1280041.
2
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Biochem J. 1968 Dec;110(4):687-92. doi: 10.1042/bj1100687.
3
The enzymic degradation of L-serine O-sulphate by a specific system from pig liver. Studies on the mechanism of the reaction.猪肝特定系统对L-丝氨酸O-硫酸盐的酶促降解。反应机制研究。
Biochem J. 1972 Jan;126(1):187-91. doi: 10.1042/bj1260187.
4
Studies on the enzymic degradation of L-serine O-sulphate by a rat liver preparation.大鼠肝脏制剂对L-丝氨酸O-硫酸酯的酶促降解研究。
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The inhibition of glutamate dehydrogenase by L-serine O-sulphate and related compounds and by photo-oxidation in the presence of Rose Bengal.L-丝氨酸O-硫酸酯及相关化合物以及在孟加拉玫瑰红存在下通过光氧化对谷氨酸脱氢酶的抑制作用。
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L-histidine ammonia-lyase in rat liver. I. Purification and general characteristics.大鼠肝脏中的L-组氨酸解氨酶。I. 纯化及一般特性
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From Glucose to Lactate and Transiting Intermediates Through Mitochondria, Bypassing Pyruvate Kinase: Considerations for Cells Exhibiting Dimeric PKM2 or Otherwise Inhibited Kinase Activity.从葡萄糖到乳酸以及通过线粒体的过渡中间体，绕过丙酮酸激酶：对表现出二聚体PKM2或其他激酶活性受抑制的细胞的考量
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本文引用的文献

1
The metabolism of potassium l-serine O[S]-sulphate in the rat.大鼠中L-丝氨酸O[S]-硫酸盐的代谢
Biochem J. 1962 Dec;85(3):456-60. doi: 10.1042/bj0850456.
2
The spectrophotometric determination of tyrosine and tryptophan in proteins.蛋白质中酪氨酸和色氨酸的分光光度测定法。
Biochem J. 1946;40(5-6):628-32. doi: 10.1042/bj0400628.
3
A rat liver system that catalyses a pyridoxal phosphate-independent alpha beta-eliminto.一种催化不依赖磷酸吡哆醛的αβ消除反应的大鼠肝脏系统。
Biochem J. 1969 Sep;114(2):299-305. doi: 10.1042/bj1140299.
4
Reaction of tetranitromethane with protein sulfhydryl groups. Inactivation of aldolase.四硝基甲烷与蛋白质巯基的反应。醛缩酶的失活。
Biochemistry. 1968 Apr;7(4):1525-30. doi: 10.1021/bi00844a040.
5
Studies on the enzymic degradation of L-serine O-sulphate by a rat liver preparation.大鼠肝脏制剂对L-丝氨酸O-硫酸酯的酶促降解研究。
Biochem J. 1967 Nov;105(2):467-72. doi: 10.1042/bj1050467.
6
Syncatalytic modification of a functional tyrosyl residue in aspartate aminotransferase.天冬氨酸转氨酶中一个功能性酪氨酰残基的同步催化修饰。
Biochemistry. 1970 Jul 21;9(15):3025-34. doi: 10.1021/bi00817a014.
7
On the use of tetranitromethane as a nitration reagent. The reaction of phenol side-chains in bovine and porcine trypsinogens and trypsins.关于使用四硝基甲烷作为硝化试剂。牛和猪胰蛋白酶原及胰蛋白酶中酚侧链的反应。
Eur J Biochem. 1970 Feb;12(2):250-7. doi: 10.1111/j.1432-1033.1970.tb00844.x.
8
The purification and properties of the L-serine O-sulphate degrading system of pig liver.猪肝中L-丝氨酸O-硫酸盐降解系统的纯化及性质
Biochem J. 1971 Mar;121(5):747-52. doi: 10.1042/bj1210747.
9
The enzymic degradation of L-serine O-sulphate by a specific system from pig liver. Studies on the mechanism of the reaction.猪肝特定系统对L-丝氨酸O-硫酸盐的酶促降解。反应机制研究。
Biochem J. 1972 Jan;126(1):187-91. doi: 10.1042/bj1260187.
10
The inhibition of glutamate dehydrogenase by L-serine O-sulphate and related compounds and by photo-oxidation in the presence of Rose Bengal.L-丝氨酸O-硫酸酯及相关化合物以及在孟加拉玫瑰红存在下通过光氧化对谷氨酸脱氢酶的抑制作用。
Biochem J. 1971 Jul;123(3):421-6. doi: 10.1042/bj1230421.

L-丝氨酸O-硫酸盐的酶促降解。反应机制。

The enzymic degradation of L-serine O-sulphate. Mechanism of the reaction.

作者信息

Tudball N, Thomas P

出版信息

Biochem J. 1972 Jun;128(1):41-6. doi: 10.1042/bj1280041.

DOI:10.1042/bj1280041
PMID:4673572
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1173567/
Abstract
  1. During the enzyme-catalysed degradation of l-serine O-sulphate no exchange occurs between the hydrogen atom attached to the alpha-carbon atom of the substrate and the tritiated water of the incubation medium. 2. The participation of an intermediate carbanion has been demonstrated in the degradation by performing the reaction in the presence of tetranitromethane. 3. Photo-oxidation of the enzyme in the presence of Rose Bengal led to a rapid inactivation of enzyme with the concomitant loss of four histidine residues/molecule. 4. Rose Bengal was also a non-competitive inhibitor of the enzyme.
摘要
  1. 在l-丝氨酸O-硫酸盐的酶催化降解过程中，底物α-碳原子上连接的氢原子与孵育介质中的氚水之间不发生交换。2. 通过在四硝基甲烷存在下进行反应，已证明中间体碳负离子参与了降解过程。3. 在孟加拉玫瑰红存在下对该酶进行光氧化导致酶迅速失活，同时每个分子损失四个组氨酸残基。4. 孟加拉玫瑰红也是该酶的非竞争性抑制剂。