Anisimov V N
Endokrinologie. 1979 Feb;73(1):6-10.
The administration of histamine dihydrochloride (5 micrograms) into the lateral brain ventricle, H1-agonist IEM-813 (0.25 mg/kg) intraperitoneally, tavegil (0.05 mg/kg) intraperitoneally and dimedrol (50 mg/kg) subcutaneously did not change the rate of compensatory ovarian hypertrophy (COH) in hemiovariectomized rats. The treatment of rats with histamine or IEM-813 prevented the suppressive action of diethystilbestrol on COH, tavegil did not change and dimedrol enhanced the estrogen effect. Central histaminergic structures are suggested not be involved in the mechanism of PSH secretion. However, their stimulation inhibits the realisation of the negative feedback of estrogen.
向半侧卵巢切除大鼠的侧脑室注射二盐酸组胺（5微克）、腹腔注射H1激动剂IEM - 813（0.25毫克/千克）、腹腔注射塔维吉尔（0.05毫克/千克）以及皮下注射苯海拉明（50毫克/千克），均未改变代偿性卵巢肥大（COH）的发生率。用组胺或IEM - 813处理大鼠可防止己烯雌酚对COH的抑制作用，塔维吉尔无此作用，而苯海拉明增强了雌激素效应。提示中枢组胺能结构不参与垂体促性腺激素（PSH）分泌机制。然而，对其刺激会抑制雌激素负反馈的实现。
