Anisimov V N
Probl Endokrinol (Mosk). 1978 Sep-Oct;24(5):85-7.
Stimulation of the n-cholinergic structures by nicotine or depression of m-cholinergic structures by metamizyl inhibited the compensatory ovarian hypertrophy (COH) induced by hemiovariectomy in rats. Stimulation of m-cholinergic structure by arecoline or depression of n-cholinergic structures by n-cholinolytic IEM-506 eliminated the suppression of COH induced by diethylstilbestrol-propionate. The mediatory role of the central-m-cholinergic systems in the mechanisms of COH and that of n-cholinergic systems in the estrogen-induced suppression of COH is suggested.
尼古丁对N-胆碱能结构的刺激或安乃近对M-胆碱能结构的抑制，均可抑制大鼠半卵巢切除诱导的代偿性卵巢肥大（COH）。槟榔碱对M-胆碱能结构的刺激或N-胆碱解抗剂IEM-506对N-胆碱能结构的抑制，均可消除己烯雌酚丙酸酯诱导的COH抑制作用。这提示中枢M-胆碱能系统在COH机制中起介导作用，而N-胆碱能系统在雌激素诱导的COH抑制中起介导作用。
