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1
Complement and phospholipase C lysis of lipid membranes.脂质膜的补体和磷脂酶C裂解作用
Immunology. 1972 Nov;23(5):705-11.
2
Studies on the terminal stages of complement lysis.补体溶解终末阶段的研究。
Immunology. 1973 Jan;24(1):135-45.
3
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Tanpakushitsu Kakusan Koso. 1974 Sep 17;19(10):741-54.
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Fate of phospholipids in liposomal model membranes damaged by antibody and complement.抗体和补体损伤的脂质体模型膜中磷脂的命运
Biochemistry. 1970 Nov 24;9(24):4767-76. doi: 10.1021/bi00826a021.
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Complement: effects of C1 binding affinity on the efficiency of the C2 reaction.补体：C1结合亲和力对C2反应效率的影响
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6
Comparative responses of liposomes prepared with different ceramide antigens to antibody and complement.
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7
Preparation of immunologically responsive liposomes with phosphonyl and phosphinyl analogs of lecithin.用卵磷脂的膦酰基和次膦酰基类似物制备免疫反应性脂质体。
Biochim Biophys Acta. 1971 Jun 1;233(3):815-9. doi: 10.1016/0005-2736(71)90183-0.
8
Release of macromolecular markers (enzymes) from liposomes treated with antibody and complement. An attempt at correlation with electron microscopic observations.抗体和补体处理的脂质体中大分子标志物（酶）的释放。与电子显微镜观察结果的相关性研究。
Biochim Biophys Acta. 1973 Mar 16;298(2):158-79. doi: 10.1016/0005-2736(73)90347-7.
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Immunochemical quantitaion of the third component of guinea pig complement in fluid phase and bound to cell surfaces.豚鼠补体第三成分在液相及结合于细胞表面的免疫化学定量分析。
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On the mechanism of membrane damage by complement: the effect of length and unsaturation of the acyl chains in liposomal bilayers and the effect of cholesterol concentration in sheep erythrocyte and liposomal membranes.关于补体对膜损伤的机制：脂质体双层中酰基链长度和不饱和度的影响以及绵羊红细胞膜和脂质体膜中胆固醇浓度的影响。
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引用本文的文献

1
Immunochemical studies of conjugates of isomaltosyl oligosaccharides to lipid. I. Antigenicity of the glycolipids and the production of specific antibodies in rabbits.异麦芽糖基寡糖与脂质缀合物的免疫化学研究。I. 糖脂的抗原性及兔体内特异性抗体的产生
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Z Parasitenkd. 1983;69(4):415-24. doi: 10.1007/BF00927697.
3
Synthesis of lipids or lipid-containing macromolecules in tumor cells. Relevance to host defense.肿瘤细胞中脂质或含脂质大分子的合成。与宿主防御的相关性。
Surv Immunol Res. 1983;2(2):122-8. doi: 10.1007/BF02918569.
4
Alteration of human erythrocyte membrane properties by complement fixation.补体结合对人红细胞膜特性的改变。
J Clin Invest. 1975 Apr;55(4):675-80. doi: 10.1172/JCI107976.
5
Release of 14C label and complement killing of Escherichia coli.14C标记的释放及大肠杆菌的补体杀伤作用
Immunology. 1975 Mar;28(3):391-400.

本文引用的文献

1
SOME OBSERVATIONS ON THE SPECIFICITY OF PHOSPHOLIPASE A.关于磷脂酶A特异性的一些观察
Biochim Biophys Acta. 1964 Feb 24;84:41-54. doi: 10.1016/0926-6542(64)90099-x.
2
Hydrolysis of synthetic mixed-acid phosphatides by phospholipase A from human pancreas.人胰腺磷脂酶A对合成混合酸磷脂的水解作用。
Biochim Biophys Acta. 1963 Feb 12;67:295-304.
3
Hydrolysis of synthetic phosphatides by Clostridium welchii phosphatidase.韦氏梭菌磷脂酶对合成磷脂的水解作用。
Biochem Biophys Res Commun. 1961 Mar 10;4:183-8. doi: 10.1016/0006-291x(61)90267-4.
4
Hemolytic activity of lipoprotein-depleted serum and the effect of certain anions on complement.脂蛋白缺乏血清的溶血活性及某些阴离子对补体的影响。
J Immunol. 1966 Nov;97(5):680-5.
5
Anaphylaxis in isolated rat mast cells. IV. Studies on the possible role of lysolecithin as an agent responsible for immune cellular injury.大鼠离体肥大细胞中的过敏反应。IV. 溶血卵磷脂作为免疫细胞损伤介质的可能作用的研究。
Int Arch Allergy Appl Immunol. 1965;28(4):201-16.
6
Investigations on cellular blood-group substances. I. Isolation and chemical composition of blood-group ABH and Le-b isoantigens of sphingoglycolipid nature.血细胞血型物质的研究。I. 具有鞘糖脂性质的ABH血型和Le-b血型同种抗原的分离及化学成分
Biochemistry. 1968 Apr;7(4):1279-86. doi: 10.1021/bi00844a005.
7
Quantitative measurement of guinea pig complement with liposomes.
J Immunol. 1971 Jan;106(1):258-65.
8
Complement-mediated lysis of liposomes produced by the reactive lysis procedure.通过反应性裂解程序产生的补体介导的脂质体裂解。
Immunology. 1970 Dec;19(6):983-6.
9
Fate of phospholipids in liposomal model membranes damaged by antibody and complement.抗体和补体损伤的脂质体模型膜中磷脂的命运
Biochemistry. 1970 Nov 24;9(24):4767-76. doi: 10.1021/bi00826a021.
10
Complement-dependent damage to liposomes prepared from pure lipids and Forssman hapten.补体依赖的对由纯脂质和福斯曼半抗原制备的脂质体的损伤。
Biochemistry. 1969 Oct;8(10):4149-58. doi: 10.1021/bi00838a036.

脂质膜的补体和磷脂酶C裂解作用

Complement and phospholipase C lysis of lipid membranes.

作者信息

Hesketh T R, Payne S N, Humphrey J H

出版信息

Immunology. 1972 Nov;23(5):705-11.

PMID:4673869
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1407964/
Abstract

Disruption by activated complement of liposomal membranes containing phospholipids can occur whether or not cholesterol is present and whether or not the phospholipids contain unsaturated fatty acid residues. Certain membrane structures, susceptible to the action of complement, were not disrupted by phospholipase C. We conclude that the terminal stages of complement lysis do not involve enzymatic cleavage of the C-O-P linkage in phospholipids.

摘要

无论是否存在胆固醇，也无论磷脂是否含有不饱和脂肪酸残基，活化补体都可能破坏含磷脂的脂质体膜。某些易受补体作用影响的膜结构不会被磷脂酶C破坏。我们得出结论，补体溶解的终末阶段不涉及磷脂中C-O-P键的酶促裂解。