脂质膜的补体和磷脂酶C裂解作用
Complement and phospholipase C lysis of lipid membranes.
作者信息
Hesketh T R, Payne S N, Humphrey J H
出版信息
Immunology. 1972 Nov;23(5):705-11.
Abstract
Disruption by activated complement of liposomal membranes containing phospholipids can occur whether or not cholesterol is present and whether or not the phospholipids contain unsaturated fatty acid residues. Certain membrane structures, susceptible to the action of complement, were not disrupted by phospholipase C. We conclude that the terminal stages of complement lysis do not involve enzymatic cleavage of the C-O-P linkage in phospholipids.
摘要
无论是否存在胆固醇，也无论磷脂是否含有不饱和脂肪酸残基，活化补体都可能破坏含磷脂的脂质体膜。某些易受补体作用影响的膜结构不会被磷脂酶C破坏。我们得出结论，补体溶解的终末阶段不涉及磷脂中C-O-P键的酶促裂解。
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