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流感流行后出生儿童的肿瘤发病率。

Incidence of neoplasms in children born after influenza epidemics.

作者信息

Leck I, Steward J K

出版信息

Br Med J. 1972 Dec 16;4(5841):631-4. doi: 10.1136/bmj.4.5841.631.

Abstract

Following a recent report that neoplasia of the lymphatic and haematopoietic tissues is commoner than average in children whose mothers have had influenza in pregnancy, the incidence of neoplasms in 1954-68 in children of the Manchester Hospital Region was examined in relation to date of birth. There were no significant differences between cohorts born in different quinquennia. Incidence among children born after six influenza epidemics in 1951-68 was no higher than among other children born in these years. It is concluded that if there is an association between maternal influenza and childhood neoplasia it is probably due to factors such as immunological deficiencies which may predispose independently to both conditions.

摘要

最近有报告称,母亲在孕期患流感的儿童,其淋巴和造血组织肿瘤的发病率高于平均水平。据此,研究人员对曼彻斯特医院地区1954年至1968年出生儿童的肿瘤发病率与出生日期的关系进行了调查。不同五年期出生的队列之间没有显著差异。1951年至1968年经历六次流感流行后出生的儿童,其发病率并不高于这些年份出生的其他儿童。研究得出结论,如果母亲患流感与儿童肿瘤之间存在关联,可能是由于免疫缺陷等因素,这些因素可能独立地使个体易患这两种疾病。

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