Roman E, Ansell P, Bull D
Leukaemia Research Fund, Centre for Clinical Epidemiology, Leeds, UK.
Br J Cancer. 1997;76(3):406-15. doi: 10.1038/bjc.1997.399.
A medical record-based study of leukaemia and non-Hodgkin's lymphoma diagnosed before the age of 30 years was carried out at three hospitals in the south of England. Findings for 177 cases and 354 age- and sex-matched controls are presented here. For documented viral infection in pregnancy, the odds ratio (OR) was 6.0 [95% confidence interval (CI) 1.2-29.7] for leukaemia and infinity (95% CI 1.24-infinity) for non-Hodgkin's lymphoma. Mothers of leukaemic cases were more likely to be anaemic, the OR for a pregnancy haemoglobin below 10 g being 3.8 (95% CI 1.3-11.1). An association with birthweight was found for acute myeloid leukaemia, the OR for birthweights > 3500 g being 6.2 (95% CI 1.3-29.8). Further, the preceding siblings of those diagnosed with any form of leukaemia were also more likely to weigh > 3500 g at birth (OR 2.2; 95% CI 1.1-4.4). Overall, leukaemic cases appeared to be comparatively robust at birth with respect to other indicators of well-being, the ORs for jaundice, phototherapy, admission to special care nursery and neonatal intensive care all being less than 1.0. Further, no relation between childhood leukaemia and neonatal administration of intramuscular vitamin K was noted (OR 0.6, 95% CI 0.3-1.4; for acute lymphoblastic leukaemia diagnosed between the ages of 1 and 6 years).
在英格兰南部的三家医院开展了一项基于病历的研究，研究对象为30岁之前确诊的白血病和非霍奇金淋巴瘤患者。本文呈现了177例患者及354名年龄和性别匹配的对照的研究结果。对于孕期有病毒感染记录的情况，白血病的比值比（OR）为6.0[95%置信区间（CI）1.2 - 29.7]，非霍奇金淋巴瘤的比值比为无穷大（95%CI 1.24 - 无穷大）。白血病患者的母亲更易患贫血，孕期血红蛋白低于10g的OR为3.8（95%CI 1.3 - 11.1）。发现急性髓系白血病与出生体重有关，出生体重>3500g的OR为6.2（95%CI 1.3 - 29.8）。此外，被诊断为任何形式白血病患者的前同胞出生时体重>3500g的可能性也更高（OR 2.2；95%CI 1.1 - 4.4）。总体而言，就其他健康指标而言，白血病患者出生时似乎相对健康，黄疸、光疗、入住特殊护理病房和新生儿重症监护的OR均小于1.0。此外，未发现儿童白血病与新生儿肌肉注射维生素K之间存在关联（OR 0.6，95%CI 0.3 - 1.4；针对1至6岁确诊的急性淋巴细胞白血病）。
