Von Burg R, Conroy P J
Eur J Pharmacol. 1979 May 15;55(4):417-20. doi: 10.1016/0014-2999(79)90118-3.
Contrary to an earlier report that metronidazole exhibited anticholinesterase activity on isolated organ preparations, a direct spectrophotometric assay was unable to demonstrate any significant inhibition of either true or pseudocholinesterase activity in the presence of this drug. The related nitroimidazole, misonidazole, was also found to be inactive when tested in this system. This report demonstrates that the clinical neurotoxicity of these two compounds cannot be attributed to any direct effect on the cholinesterase enzymes.
与之前关于甲硝唑在离体器官制剂上表现出抗胆碱酯酶活性的报道相反，直接分光光度法测定未能证明在该药物存在下对真性或假性胆碱酯酶活性有任何显著抑制作用。相关的硝基咪唑米索硝唑在该系统中测试时也被发现无活性。本报告表明，这两种化合物的临床神经毒性不能归因于对胆碱酯酶的任何直接作用。
