Clarke C, Hobbiger F, Sheldon P W
Eur J Pharmacol. 1981 Jan 16;69(2):209-11. doi: 10.1016/0014-2999(81)90416-7.
The acetylcholinesterase and cholinesterase activities in the mouse cerebellum were unchanged following misonidazole treatment. Inhibition of acetylcholinesterase activity only occurred at concentrations of misonidazole which were in excess of those obtained clinically. These findings indicate that the clinical neurotoxicity of the drug cannot be attributed to an effect on cholinesterases.
用米索硝唑治疗后，小鼠小脑内的乙酰胆碱酯酶和胆碱酯酶活性未发生变化。仅在米索硝唑浓度超过临床所获浓度时，才会出现乙酰胆碱酯酶活性受到抑制的情况。这些研究结果表明，该药物的临床神经毒性不能归因于对胆碱酯酶的影响。
