Spierings E L, Saxena P R
Eur J Pharmacol. 1979 Jun;56(1-2):31-7. doi: 10.1016/0014-2999(79)90429-1.
The effect of the antimigraine drug, ergotamine, was studied on the distribution of flow throughout the cranial microcirculation of the cat, using microspheres suitable in size to separate capillary flow from flow through the arteriovenous anastomoses. A constant flow perfusion experiment was used in order to eliminate the secondary effect of ergotamine on the microcirculation through a reduction in carotid blood flow per se. Under the experimental conditions, ergotamine decreased in a dose-dependent way the fraction of perfusion flow shunted through the arteriovenous anastomoses. This mode of action of ergotamine sheds new light on the so-called migraine shunt theory.
使用大小适合区分毛细血管血流与动静脉吻合支血流的微球，研究了抗偏头痛药物麦角胺对猫颅部微循环血流分布的影响。采用恒流灌注实验，以消除麦角胺本身通过减少颈动脉血流对微循环产生的继发效应。在实验条件下，麦角胺以剂量依赖方式减少了通过动静脉吻合支分流的灌注血流比例。麦角胺的这种作用方式为所谓的偏头痛分流理论提供了新的线索。
