Stavorovsky M, Lichtenstein D, Nissim F
Dermatologica. 1979;158(6):451-61. doi: 10.1159/000250797.
The appearance of petechiae and ecchymoses following anticoagulant and fibrinolytic therapy is an unusual and rare complication. The mechanism of the vasculitis is obscure but may be related to a chemical vasotoxic reaction. During anticoagulant and fibrinolytic therapy, 6 patients developed petechiae and ecchymoses which was accompanied by pain and fever. There were no disturbances of blood clotting factors. In spite of the varied action of the different anticoagulants and fibrinolytic drugs, the clinical course and the histological examination demonstrated a similar identical vasculitis.
抗凝和纤溶治疗后出现瘀点和瘀斑是一种不常见且罕见的并发症。血管炎的机制尚不清楚，但可能与化学性血管毒性反应有关。在抗凝和纤溶治疗期间，6例患者出现了瘀点和瘀斑，并伴有疼痛和发热。凝血因子没有紊乱。尽管不同的抗凝剂和纤溶药物作用各异，但临床病程和组织学检查显示出相似的相同血管炎。
