Car N, Naranscik P, Gamulin S
Exp Cell Biol. 1979;47(4):250-7. doi: 10.1159/000162943.
Cadmium injected to mice provokes an acute disaggregation of hepatic polyribosomes. The effect appears within 15 min, it is maximal after 1 h and then gradually disappears. The reaggregation of polyribosomes takes place 6--12 h after injection. The disaggregation of polyribosomes is linear with log doses in a range of 7.25--20 mumol/kg CdCl2. Cycloheximide pretreatment prevents the disaggregation of polyribosomes in the livers of cadmium-treated mice.
给小鼠注射镉会引发肝脏多核糖体的急性解聚。这种效应在15分钟内出现，1小时后达到最大，然后逐渐消失。多核糖体在注射后6至12小时重新聚集。在7.25至20微摩尔/千克氯化镉的剂量范围内，多核糖体的解聚与对数剂量呈线性关系。环己酰亚胺预处理可防止镉处理小鼠肝脏中多核糖体的解聚。
