Toge T, Nagusa Y, Nakano A, Ikeda H, Hattori T
Gan. 1979 Apr;70(2):245-8.
Lymphocyte responsiveness in stimulation with phytohemagglutinin (PHA) and the inhibitory effect of autologous serum on lymphocyte responsiveness were investigated in 55 patients with breast cancer. Lymphocytes from patients, even in the late stage of the disease, as well as from normal healthy control, showed an ability to respond to the stimulation with PHA in the presence of pooled normal serum, while lymphocyte responsiveness in the presence of autologous serum was markedly reduced in stage III and IV patients. Similar result was found in the examination of lymphocyte responsiveness with relation to tumor size, where lymphocytes from patients with a large tumor of more than 5 cm in diameter were less responsive when cultured with autologous serum. From these results, it is reasonable to conclude that in patients with breast cancer, the apparent reduction of lymphocyte reactivity may be due to serum inhibitor that may adhere to the lymphocytes, rather than a primary lymphocyte impairment.
对55例乳腺癌患者进行了研究，观察其淋巴细胞对植物血凝素（PHA）刺激的反应性以及自体血清对淋巴细胞反应性的抑制作用。即使处于疾病晚期的患者的淋巴细胞，以及正常健康对照者的淋巴细胞，在存在混合正常血清的情况下，均显示出对PHA刺激的反应能力，而在III期和IV期患者中，存在自体血清时淋巴细胞反应性明显降低。在检查与肿瘤大小相关的淋巴细胞反应性时也发现了类似结果，即直径大于5 cm的大肿瘤患者的淋巴细胞在与自体血清一起培养时反应性较低。从这些结果可以合理地得出结论，在乳腺癌患者中，淋巴细胞反应性的明显降低可能是由于血清抑制剂可能附着于淋巴细胞，而不是原发性淋巴细胞损伤。
