Toge T, Oride M, Yanagawa E, Hamamoto S, Kohno H, Nakanishi K, Hattori T
Jpn J Surg. 1982;12(6):424-8. doi: 10.1007/BF02469832.
In 501 Japanese patients with gastric cancer, the relationships between preoperative lymphocyte proliferative (LP) responses to mitogens and prognosis of patients were evaluated. Peripheral blood lymphocytes were cultured in the presence of either autologous or allogeneic serum and their LP responses to phytohemagglutinin (PHA) and pokeweed mitogen were investigated. An apparent inverse relationship between LP responses and stage of the disease was found in LP responses to PHA in the presence of autologous serum. The survival rate of patients with higher responses was significantly greater than those with lower responses, when LP responses to PHA in the presence of autologous serum served as the criterion. Probabilities of staging which were computed on the basis of LP response to PHA affirmed the reciprocal relationship between LP responses and stage of the disease. From these results, it is concluded that evaluation of LP responses may be a valuable tool in the assessment of the clinical stage and in the prediction of prognosis.
对501例日本胃癌患者，评估术前淋巴细胞对丝裂原的增殖（LP）反应与患者预后之间的关系。将外周血淋巴细胞在自体或异体血清存在的情况下进行培养，并研究其对植物血凝素（PHA）和商陆丝裂原的LP反应。在自体血清存在的情况下，PHA的LP反应中发现LP反应与疾病分期之间存在明显的负相关关系。以自体血清存在时PHA的LP反应为标准，反应较高的患者生存率明显高于反应较低的患者。根据对PHA的LP反应计算出的分期概率证实了LP反应与疾病分期之间的反比关系。从这些结果可以得出结论，LP反应的评估可能是评估临床分期和预测预后的有价值工具。
