Guix M, Skinner J M, Whitehead R
Gut. 1979 Jun;20(6):504-8. doi: 10.1136/gut.20.6.504.
By accurate morphometry the length of the rough endoplasmic reticulum (RER) was estimated in electron micrographs of a population of jejunal plasma cells in biopsies obtained from normal volunteers, untreated coeliac disease patients, and coeliac disease patients treated for one year on a gluten free diet. Increase in length or hypertrophy of the endoplasmic reticulum is an indication of increased protein synthesis of the cell (Ghadially, 1977). An increase compared with normal length was demonstrated in the mean length of the plasma cell rough endoplasmic reticulum in plasma cells obtained from both groups of coeliac patients. This estimate of increased protein production--in this case immunoglobulin--indicates an increase in the immunological activity of plasma cells even after treatment and suggests not only a reaction to dietary gluten but probably to other antigens also.
通过精确的形态测量法，在取自正常志愿者、未经治疗的乳糜泻患者以及接受无麸质饮食治疗一年的乳糜泻患者的活检组织中，对空肠浆细胞群体的电子显微照片中的粗面内质网（RER）长度进行了估计。内质网长度增加或肥大表明细胞的蛋白质合成增加（加迪亚利，1977年）。两组乳糜泻患者的浆细胞中，浆细胞粗面内质网的平均长度均显示出较正常长度有所增加。这种蛋白质产生增加的估计——在这种情况下是免疫球蛋白——表明即使在治疗后浆细胞的免疫活性也有所增加，这不仅提示了对饮食中麸质的反应，可能还提示了对其他抗原的反应。
