雪白链霉菌对新生霉素的生物合成。
Biosynthesis of novobiocin by Streptomyces niveus.
作者信息
Kominek L A
出版信息
Antimicrob Agents Chemother. 1972 Feb;1(2):123-34. doi: 10.1128/AAC.1.2.123.
Abstract
Streptomyces niveus in a chemically defined medium requires the inclusion of Krebs cycle acids for good growth. These acids are used in preference to glucose, and this results in diauxic growth. Studies with washed cells, cell-free extracts, and mutants of S. niveus were performed to determine the mode of synthesis of the individual ring systems of novobiocin and their linkage. A pathway for novobiocin synthesis is proposed on the basis of these experiments.
摘要
在化学成分确定的培养基中，雪白链霉菌生长良好需要加入三羧酸循环的酸类物质。这些酸类物质比葡萄糖更受青睐，这导致了二次生长。对雪白链霉菌的洗涤细胞、无细胞提取物和突变体进行了研究，以确定新生霉素各个环系统的合成模式及其连接方式。基于这些实验，提出了一条新生霉素的合成途径。
相似文献
1
Biosynthesis of novobiocin by Streptomyces niveus.雪白链霉菌对新生霉素的生物合成。
Antimicrob Agents Chemother. 1972 Feb;1(2):123-34. doi: 10.1128/AAC.1.2.123.
2
Induction of resistance to novobiocin in the novobiocin-producing organism Streptomyces niveus.在新霉素产生菌雪白链霉菌中诱导对新霉素的抗性。
FEMS Microbiol Lett. 1994 Feb 15;116(2):131-6. doi: 10.1111/j.1574-6968.1994.tb06691.x.
3
Studies on the biosynthesis of terpenoid compounds produced by actinomycetes. 3. Biosynthesis of the isoprenoid side chain of novobiocin via the non-mevalonate pathway in Streptomyces niveus.放线菌产生的萜类化合物的生物合成研究。3. 雪白链霉菌中通过非甲羟戊酸途径合成新生霉素的类异戊二烯侧链。
J Antibiot (Tokyo). 1998 Jul;51(7):676-8. doi: 10.7164/antibiotics.51.676.
4
Expression of novobiocin resistance genes in the novobiocin-producing organism Streptomyces niveus.新生霉素产生菌雪白链霉菌中新生霉素抗性基因的表达
J Appl Bacteriol. 1995 May;78(5):543-7. doi: 10.1111/j.1365-2672.1995.tb03097.x.
5
6
[Activity of certain enzymes in Actinomyces spheroides and the action of novobiocin].[球状放线菌中某些酶的活性及新生霉素的作用]
Mikrobiologiia. 1974;43(3):484-8.
7
High frequency transformation of Streptomyces niveus protoplasts by plasmid DNA.质粒DNA对雪白链霉菌原生质体的高频转化
J Appl Bacteriol. 1991 Nov;71(5):422-7. doi: 10.1111/j.1365-2672.1991.tb03811.x.
8
[Effect of the phosphorus concentration on novobiocin formation by the producer Act. spheroides].[磷浓度对产生菌球形节杆菌合成新生霉素的影响]
Antibiotiki. 1975 Oct;20(10):871-6.
9
Degeneration of Streptomyces niveus with repeated transfers.多次传代导致雪白链霉菌退化。
Appl Microbiol. 1961 Jul;9(4):342-5. doi: 10.1128/am.9.4.342-345.1961.
引用本文的文献
1
Cell-Free Gene Expression: Methods and Applications.无细胞基因表达：方法与应用
Chem Rev. 2025 Jan 8;125(1):91-149. doi: 10.1021/acs.chemrev.4c00116. Epub 2024 Dec 19.
2
Comparison of Actinobacteria communities from human-impacted and pristine karst caves.比较人为影响和原始喀斯特洞穴中的放线菌群落。
Microbiologyopen. 2022 Feb;11(2):e1276. doi: 10.1002/mbo3.1276.
3
Heterologous expression of a putative ClpC chaperone gene leads to induction of a host metabolite.一个假定的ClpC伴侣蛋白基因的异源表达导致一种宿主代谢物的诱导。
J Braz Chem Soc. 2019 Mar;30(3):499-508. doi: 10.21577/0103-5053.20180234.
4
Diversity and Applications of Endophytic Actinobacteria of Plants in Special and Other Ecological Niches.植物内生放线菌在特殊及其他生态位中的多样性与应用
Front Microbiol. 2018 Aug 8;9:1767. doi: 10.3389/fmicb.2018.01767. eCollection 2018.
5
Characterization of DNA Binding Sites of RokB, a ROK-Family Regulator from Streptomyces coelicolor Reveals the RokB Regulon.天蓝色链霉菌ROK家族调控因子RokB的DNA结合位点表征揭示了RokB调控子
PLoS One. 2016 May 4;11(5):e0153249. doi: 10.1371/journal.pone.0153249. eCollection 2016.
6
Taxonomy, Physiology, and Natural Products of Actinobacteria.放线菌的分类学、生理学与天然产物
Microbiol Mol Biol Rev. 2015 Nov 25;80(1):1-43. doi: 10.1128/MMBR.00019-15. Print 2016 Mar.
7
Heterologous expression of the thiopeptide antibiotic GE2270 from Planobispora rosea ATCC 53733 in Streptomyces coelicolor requires deletion of ribosomal genes from the expression construct.来自玫瑰扁平双孢菌ATCC 53733的硫肽类抗生素GE2270在天蓝色链霉菌中的异源表达需要从表达构建体中删除核糖体基因。
PLoS One. 2014 Mar 5;9(3):e90499. doi: 10.1371/journal.pone.0090499. eCollection 2014.
8
Five gene products are required for assembly of the central pyrrole moiety of coumermycin A1.五个基因产物对于装配累积霉素 A1 的中心吡咯环部分是必需的。
J Ind Microbiol Biotechnol. 2013 Aug;40(8):915-25. doi: 10.1007/s10295-013-1266-6. Epub 2013 May 8.
9
CloQ, a prenyltransferase involved in clorobiocin biosynthesis.CloQ，一种参与氯新生霉素生物合成的异戊烯基转移酶。
Proc Natl Acad Sci U S A. 2003 Mar 4;100(5):2316-21. doi: 10.1073/pnas.0337708100.
10
Identification of the novobiocin biosynthetic gene cluster of Streptomyces spheroides NCIB 11891.球形链霉菌NCIB 11891新生霉素生物合成基因簇的鉴定
Antimicrob Agents Chemother. 2000 May;44(5):1214-22. doi: 10.1128/AAC.44.5.1214-1222.2000.
本文引用的文献
1
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
2
SECONDARY METABOLISM: AN EXPLANATION IN TERMS OF INDUCED ENZYME MECHANISMS.
Experientia. 1965 Jan 15;21:55-6. doi: 10.1007/BF02136383.
3
The biosynthesis of noviose, a branched-chain monosaccharide.
Biochim Biophys Acta. 1962 Feb 12;57:143-5. doi: 10.1016/0006-3002(62)91090-9.
4
Novobiocin.新生霉素
Prog Ind Microbiol. 1961;3:91-139.
5
Assay methods for novobiocin.新生霉素的测定方法。
Antibiot Annu. 1957;5:43-52.
6
A photometric method for the determination of proline.一种测定脯氨酸的光度法。
J Biol Chem. 1955 Aug;215(2):655-60.
7
8
Alteration of glucose metabolism of Arthrobacter crystallopoietes by compounds which induce sphere to rod morphogenesis.通过诱导球状至杆状形态发生的化合物对产晶体节杆菌葡萄糖代谢的改变。
J Bacteriol. 1969 Feb;97(2):526-34. doi: 10.1128/jb.97.2.526-534.1969.
9
O-demethyldecarbamoylnovobiocin.O-去甲基脱氨甲酰新生霉素
J Med Chem. 1968 Nov;11(6):1228-9. doi: 10.1021/jm00312a030.
10
Regulation of enzymes of glucose metabolism by citrate in Pseudomonas aeruginosa.铜绿假单胞菌中柠檬酸盐对葡萄糖代谢酶的调控
Biochem J. 1967 Sep;104(3):48P.
Zotero 插件