人胰岛素原序列71 - 86的合成，III：经由片段71 - 78和79 - 86的合成（作者译）
[Synthesis of the human proinsulin sequence 71-86, III: Synthesis via the fragments 71-78 and 79-86 (author's transl)].
作者信息
Berndt H
出版信息
Hoppe Seylers Z Physiol Chem. 1979 Jun;360(6):765-72.
PMID:468116
Abstract
The synthesis of the sequence 71-86 (XIII) of human proinsulin (sequence 6-21 of human insulin-A-chain) via the fragments 71-78 (XIy1,3) and 79-86 (XII) is described. The good solubility of the protected peptide derivatives belonging to the sequences 75-78 (IXx1,2), 79-86 (X), and 71-78 (XIy1,2), and of the fragment 71-86 (XIII) itself in organic solvents allows a quick and efficient purification of these derivatives by liquid chromatography on silica-gel columns.
摘要
描述了通过片段71 - 78（XIy1,3）和79 - 86（XII）合成人胰岛素原序列71 - 86（XIII）（人胰岛素A链序列6 - 21）的过程。属于序列75 - 78（IXx1,2）、79 - 86（X）和71 - 78（XIy1,2）的受保护肽衍生物以及片段71 - 86（XIII）本身在有机溶剂中的良好溶解性，使得通过硅胶柱液相色谱法能够快速有效地纯化这些衍生物。
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