Griggs H G, Bender M A
Science. 1973 Jan 5;179(4068):86-8. doi: 10.1126/science.179.4068.86.
Ultraviolet induces only chromatid-type aberrations in synchronized G(1) V-79 Chinese hamster and A8W243 Xenopus tissue culture cells. Posttreatment with white light prevents expression of most potential aberrations in the A8 toad cell, which possesses a photoreactivation enzyme. We conclude that the major ultraviolet-induced DNA lesion leading to chromosomal aberrations is the pyrimidine dimer.
紫外线仅在同步化的G(1)期中国仓鼠V-79细胞和非洲爪蟾A8W243组织培养细胞中诱导染色单体型畸变。用白光进行后处理可阻止具有光复活酶的A8蟾蜍细胞中大多数潜在畸变的表达。我们得出结论，导致染色体畸变的主要紫外线诱导的DNA损伤是嘧啶二聚体。
