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萎缩性胃黏膜中增殖内分泌细胞的精细结构特征

A fine structural characterization of the proliferated endocrine cells in atrophic gastric mucosa.

作者信息

Rubin W

出版信息

Am J Pathol. 1973 Jan;70(1):109-18.

PMID:4682835
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1903915/
Abstract

This study shows that most of the proliferated endocrine cells in nonintestinalized epithelium in the body of stomachs in patients with pernicious anemia have the fine structure of ECL (enterochromaffin-like) cells, the principal endocrine cell in the body of normal stomachs, and notes an absence of G (gastrin) cells, the principal endocrine cell in the normal pylorus. Since gastrin has been identified in many of these proliferated cells by immunofluorescence, these findings question the position that gastrin synthesis in the stomach is only associated with G cells.

摘要

本研究表明，恶性贫血患者胃体部未肠化生上皮中大多数增殖的内分泌细胞具有ECL（肠嗜铬样）细胞的精细结构，ECL细胞是正常胃体部的主要内分泌细胞，且研究指出正常幽门部的主要内分泌细胞G（胃泌素）细胞缺失。由于通过免疫荧光法在许多这些增殖细胞中已鉴定出胃泌素，这些发现对胃中胃泌素合成仅与G细胞相关这一观点提出了质疑。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/220b/1903915/ccccb22106ab/amjpathol00257-0119-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/220b/1903915/972806fbd277/amjpathol00257-0120-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/220b/1903915/7e01b4d55b91/amjpathol00257-0121-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/220b/1903915/ccccb22106ab/amjpathol00257-0119-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/220b/1903915/972806fbd277/amjpathol00257-0120-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/220b/1903915/7e01b4d55b91/amjpathol00257-0121-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/220b/1903915/ccccb22106ab/amjpathol00257-0119-a.jpg

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本文引用的文献

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A SIMPLIFIED LEAD CITRATE STAIN FOR USE IN ELECTRON MICROSCOPY.一种用于电子显微镜的简化柠檬酸铅染色法。
J Cell Biol. 1965 May;25(2):407-8. doi: 10.1083/jcb.25.2.407.
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The use of lead citrate at high pH as an electron-opaque stain in electron microscopy.在电子显微镜检查中，将高pH值的柠檬酸铅用作电子不透明染色剂。
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Diffuse enterochromaffin-like (ECL) cell hyperplasia and multiple gastric carcinoids: a complication of pernicious anaemia.弥漫性肠嗜铬样（ECL）细胞增生与多发性胃类癌：恶性贫血的一种并发症。
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Ultrastructural characterization of fundic endocrine cell hyperplasia associated with atrophic gastritis and hypergastrinaemia.与萎缩性胃炎和高胃泌素血症相关的胃底内分泌细胞增生的超微结构特征
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Gastric luminal somatostatin secretion of normals and patients with pernicious anemia and with Zollinger-Ellison syndrome.正常人和患有恶性贫血及卓-艾综合征患者的胃腔生长抑素分泌情况。
Dig Dis Sci. 1988 Dec;33(12):1596-600. doi: 10.1007/BF01535952.
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Inhibition of acid and gastric carcinoids.酸与胃类癌的抑制作用。
Gut. 1985 Dec;26(12):1279-83. doi: 10.1136/gut.26.12.1279.
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The biology and pathobiology of the ECL cells.肠嗜铬样细胞的生物学与病理生物学
Yale J Biol Med. 1992 Nov-Dec;65(6):761-74; discussion 827-9.
J Cell Biol. 1963 Apr;17(1):19-58. doi: 10.1083/jcb.17.1.19.
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A method for staining epoxy sections for light microscopy.一种用于光学显微镜检查的环氧树脂切片染色方法。
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Gastroenterology. 1961 Jan;40:120-6.
7
Staining of tissue sections for electron microscopy with heavy metals. II. Application of solutions containing lead and barium.用于电子显微镜检查的重金属组织切片染色。II. 含铅和钡溶液的应用。
J Biophys Biochem Cytol. 1958 Nov 25;4(6):727-30. doi: 10.1083/jcb.4.6.727.
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Intestinal heterotopia. A fine structural study.肠异位症。一项超微结构研究。
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The endocrine cells in the epithelium of the gastrointestinal mucosa of the rat. An electron microscope study.大鼠胃肠道黏膜上皮中的内分泌细胞。一项电子显微镜研究。
J Cell Biol. 1969 Mar;40(3):692-715. doi: 10.1083/jcb.40.3.692.
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Structural evidence for glucagon producing cells in the intestinal mucosa of the rat.大鼠肠黏膜中产生胰高血糖素细胞的结构证据。
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