Holloway C J, Harstick K, Brunner G
Int J Artif Organs. 1979 Mar;2(2):81-6.
A method is described for the encapsulation of ion-exchange and adsorbent resins of native particle diameter 0.2-1.0 mm into agarose spheres of diameter 5-10 mm. Plasma components diffuse rapidly through the agarose coating, but blood corpuscles have no direct access to the resins. At least 0.3 g of resin can be incorporated into 1 g of the agarose beads, so that the effective surface area with regard to erythrocytes, thrombocytes, and leucocytes is reduced by a factor of at least 5, and up to 20, depending on the native resin particle size. Pulverised active charcoal, or resins in powder form can also be encapsulated in this manner. The haemocompatibility of the agarose coating seems to be considerably more acceptable than that of the adsorbents in their native state.
描述了一种将原生粒径为0.2 - 1.0毫米的离子交换树脂和吸附树脂封装到直径为5 - 10毫米的琼脂糖球中的方法。血浆成分能迅速扩散通过琼脂糖涂层，但血细胞无法直接接触到树脂。每1克琼脂糖珠中可掺入至少0.3克树脂，这样，对于红细胞、血小板和白细胞而言，有效表面积会减少至少5倍，根据原生树脂粒径不同，最多可减少20倍。粉末状活性炭或粉末状树脂也可用这种方式封装。琼脂糖涂层的血液相容性似乎比其天然状态下的吸附剂更易于接受。
