洋地黄毒苷固体剂型的生物利用度研究。
Bioavailability study of gitoxin in a solid dosage form.
作者信息
Hupin C, de Suray J M, Versluys J, Lorent M, Dodion L, Lesne M
出版信息
Int J Clin Pharmacol Biopharm. 1979 May;17(5):197-204.
PMID:468445
Abstract
Although the cardiotonic activity of gitoxin is known for almost half a century, this digitalis glycoside has never been used in therapy, due to its apparent lack of resorption after administration by oral route. Recent studies have demonstrated that the bioavailability of gitoxin could be upraised to 100% provided it be given as a hydroalcoholic solution. The present paper deals with the development of a solid dosage form (tablets) using a physical association of gitoxin and sodium escinate.
摘要
尽管地高辛的强心活性已为人所知近半个世纪，但由于口服给药后明显缺乏吸收，这种洋地黄苷从未用于治疗。最近的研究表明，如果以水醇溶液形式给药，地高辛的生物利用度可提高到100%。本文探讨了用地高辛和七叶皂苷钠的物理缔合开发固体剂型（片剂）的问题。
相似文献
1
Bioavailability study of gitoxin in a solid dosage form.洋地黄毒苷固体剂型的生物利用度研究。
Int J Clin Pharmacol Biopharm. 1979 May;17(5):197-204.
2
Pharmacological reevaluation of gitoxin in man.
Int J Clin Pharmacol Biopharm. 1978 Oct;16(10):456-9.
3
Studies on the pharmacokinetics and the metabolism of gitoxin in the guinea-pig: I. Disposition kinetics following an i.v. bolus of 3H-gitoxin.
Arch Int Pharmacodyn Ther. 1980 May;245(1):20-41.
4
[Enhanced bioavailability of digoxin from silica matrix formulations (author's transl)].地高辛从二氧化硅基质制剂中提高的生物利用度（作者译）
Arzneimittelforschung. 1978;28(2):326-30.
5
[Biological availability of different oral cimetidine preparations in the dog].[不同口服西咪替丁制剂在犬体内的生物利用度]
Arzneimittelforschung. 1990 Jun;40(6):675-8.
6
A comparison of the bioavailability of digoxin in capsule, tablet, and solution taken orally with intravenous digoxin.口服地高辛胶囊、片剂和溶液与静脉注射地高辛的生物利用度比较。
J Clin Pharmacol. 1976 Oct;16(10 Pt 1):461-7.
7
Cardiac glycosides and their metabolites levels in plasma and heart of guinea-pigs after I. V. administration.静脉注射后豚鼠血浆和心脏中强心苷及其代谢产物的水平
Arch Int Pharmacodyn Ther. 1981 May;251(1):4-25.
8
Absolute bioavailability of digoxin tablets.地高辛片的绝对生物利用度。
Arzneimittelforschung. 1978;28(4):701-3.
9
Cardiac effects of 16-acetyl-gitoxin, the active glycoside after penta-acetyl-gitoxin administration.16-乙酰基吉他洛辛（五乙酰基吉他洛辛给药后的活性糖苷）的心脏效应
Acta Biol Med Ger. 1978;37(11-12):1713-20.
10
Pharmacokinetics, bioavailability, and dosage regimens of digoxin in dogs.
Am J Vet Res. 1980 Aug;41(8):1230-7.
引用本文的文献
1
Hepatic clearance of gitoxin: pharmacokinetic study on rabbit isolated liver. Influence of protein binding and comparison with digoxin.地高辛毒苷的肝清除率：兔离体肝脏的药代动力学研究。蛋白结合的影响及与地高辛的比较。
Eur J Drug Metab Pharmacokinet. 1983;8(1):1-8. doi: 10.1007/BF03189574.
2
The binding of gitoxin to human plasma proteins.地高辛与人类血浆蛋白的结合。
Eur J Clin Pharmacol. 1979 Nov;16(5):341-4. doi: 10.1007/BF00605633.
Zotero 插件