Creatsas G, Lolis D, Pavlatos M, Kaskarelis D
Int J Clin Pharmacol Biopharm. 1979 May;17(5):225-7.
The concentration of gentamicin in serum, menses, cervical mucus and vaginal fluid of 39 women under treatment with this antibiotic (80 mg every 8 hr i. m.) was tested by the agar diffusion method. The levels of the drug in the serum varied from 1.88-5.41 micrograms/ml with a peak one hour after the last dosage. In the menses the levels ranged from 2.06-5.87 micrograms/ml with a peak also one hour after the last dosage. The concentration of gentamicin in the cervical mucus and vaginal fluid varied from 0.67-5.14 micrograms/ml and 0.63-6.43 micrograms/ml with a peak three hours after the last administration of the drug. Results are briefly discussed.
采用琼脂扩散法检测了39名接受这种抗生素治疗（每8小时肌注80毫克）的女性血清、月经血、宫颈黏液和阴道分泌物中庆大霉素的浓度。血清中药物浓度在1.88 - 5.41微克/毫升之间，末次给药后1小时达到峰值。月经血中浓度范围为2.06 - 5.87微克/毫升，末次给药后1小时也达到峰值。宫颈黏液和阴道分泌物中庆大霉素浓度分别在0.67 - 5.14微克/毫升和0.63 - 6.43微克/毫升之间，末次给药后3小时达到峰值。对结果进行了简要讨论。
