Pak C Y
Invest Urol. 1979 Sep;17(2):146-8.
The effect of parathyroidectomy on the crystallization of calcium salts in urine was examined in seven stone-forming patients with primary hyperparathyroidism. After parathyroidectomy, urinary calcium decreased significantly from 205 +/- 30 to 67 +/- 11 mg per day (P less than 0.01); there were no significant changes in urinary phosphorus, oxalate, magnesium, sodium, potassium, uric acid, pH, or total volume. The urinary activity product ratio (state of saturation) of brushite (CaHPO4.2H2O) and calcium oxalate decreased significantly from 1.34 +/- 0.14 to 0.75 +/- 0.18 and from 3.20 +/- 0.56 to 1.53 +/- 0.21 respectively (P less than 0.05), owing principally to the decline in urinary calcium. Moreover, the urinary formation product ratio of calcium oxalate, which reflects the minimum supersaturation required for spontaneous nucleation, increased significantly after parathyroidectomy, from 7.19 +/- 1.19 to 12.99 +/- 1.69 (P less than 0.001). The results indicate that parathyroidectomy restores the normal urinary environment with respect to saturation and inhibitor and/or promoter activity.
在7例原发性甲状旁腺功能亢进的结石形成患者中，研究了甲状旁腺切除对尿中钙盐结晶的影响。甲状旁腺切除术后，尿钙显著下降，从每天205±30毫克降至67±11毫克（P<0.01）；尿磷、草酸、镁、钠、钾、尿酸、pH值或总体积无显著变化。透钙磷石（CaHPO4·2H2O）和草酸钙的尿活性产物比（饱和状态）分别从1.34±0.14显著降至0.75±0.18，从3.20±0.56显著降至1.53±0.21（P<0.05），主要是由于尿钙下降。此外，反映自发成核所需最小过饱和度的草酸钙尿生成产物比在甲状旁腺切除术后显著增加，从7.19±1.19增至12.99±1.69（P<0.001）。结果表明，甲状旁腺切除术在饱和度以及抑制剂和/或促进剂活性方面恢复了正常的尿液环境。
