婴儿的血浆地高辛水平。
Plasma digoxin levels in infants.
作者信息
O'Malley K, Coleman E N, Doig W B, Stevenson I H
出版信息
Arch Dis Child. 1973 Jan;48(1):55-7. doi: 10.1136/adc.48.1.55.
Abstract
The average dosage rate of digoxin given in a group of infants, when related to body surface area, was twice as high (and when related to body weight, five times as high) as that employed for the maintenance therapy of adult controls. The resulting plasma digoxin level in infants older than 1 month was no higher on average than that of the adult controls (1·4 ng/ml); in those younger than 1 month it was on average 2 times higher than the adults' control value yet without toxic effect. From the preliminary findings the plasma digoxin level appears to be of limited value in regulating digoxin dosage in infancy.
摘要
一组婴儿服用地高辛的平均剂量率，按体表面积计算是用于成年对照维持治疗剂量率的两倍（按体重计算则是五倍）。1个月以上婴儿由此产生的血浆地高辛水平平均不高于成年对照（1.4纳克/毫升）；1个月以下婴儿的血浆地高辛水平平均比成年对照值高两倍，但未产生毒性作用。根据初步研究结果，血浆地高辛水平在调节婴儿地高辛剂量方面价值有限。
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Simplification of drug dosage calculation by application of the surface area principle.应用体表面积原理简化药物剂量计算
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