犬类中用于DL - A单倍型分型的家族内免疫接种。

Consequent intrafamilial immunization for DL-A haplotyping in canines.

作者信息

van der Does J A, van Rood J J, Walker W S, Epstein R B

出版信息

J Exp Med. 1973 Feb 1;137(2):494-503. doi: 10.1084/jem.137.2.494.

DOI:10.1084/jem.137.2.494

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2139492/

Abstract

A procedure of intrafamilial immunization is described for production of antisera recognizing DL-A haplotypes. In a colony consisting of 1 sire, 6 bitches, and 67 offspring all haplotypes could be accurately allocated. In the colony the observed reaction frequencies of the antisera are in agreement with mendelian codominant inheritance. Mixed lymphocyte culture tests confirmed the accuracy of the serologic typing and the presence of homozygous individuals within the colony. Further evidence is presented supporting the presence of two or more subloci within the DL-A system. Colonies of canines such as the one described should provide a sensitive system for evaluating interaction between serologic DL-A typing, MLC reactivity, and immune response genetics in a nonrodent species which is not highly inbred.

摘要

描述了一种用于产生识别DL - A单倍型抗血清的家族内免疫程序。在一个由1只雄性、6只雌性和67只后代组成的群体中，所有单倍型都能被准确分配。在该群体中，抗血清的观察反应频率与孟德尔共显性遗传一致。混合淋巴细胞培养试验证实了血清学分型的准确性以及群体中纯合个体的存在。进一步的证据支持DL - A系统内存在两个或更多亚位点。像所描述的这种犬类群体应该为评估血清学DL - A分型、混合淋巴细胞培养反应性和免疫反应遗传学之间的相互作用提供一个敏感系统，该系统是一个非高度近亲繁殖的非啮齿动物物种。

相似文献

1

Consequent intrafamilial immunization for DL-A haplotyping in canines.犬类中用于DL - A单倍型分型的家族内免疫接种。

J Exp Med. 1973 Feb 1;137(2):494-503. doi: 10.1084/jem.137.2.494.

2

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10

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Histocompatibility studies in a closely bred colony of dogs. 3. Genetic definition of the DL-A system of canine histocompatibility, with particular reference to the comparative immunogenicity of the major transplantable organs.近亲繁殖犬群中的组织相容性研究。3. 犬组织相容性DL-A系统的遗传学定义，特别提及主要可移植器官的比较免疫原性。

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Determination of histocompatibility antigens by leukocyte typing in outbred guinea pigs and effect of matching on skin graft survival.远交系豚鼠白细胞分型法检测组织相容性抗原及配型对皮肤移植存活的影响

Transplant Proc. 1971 Mar;3(1):192-4.

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Hu-1: Major histocompatibility locus in man.Hu-1：人类主要组织相容性位点。

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Lymphocyte typing in allografted beagles.同种异体移植比格犬的淋巴细胞分型

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Cytotoxic typing antisera for marrow grafting in littermate dogs.用于同窝幼犬骨髓移植的细胞毒性分型抗血清。

Transplantation. 1968 Jan;6(1):45-58. doi: 10.1097/00007890-196801000-00005.

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Polymorphism of the DL-A system.

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