Dausset J, Rapaport F T, Cannon F D, Ferrebee J W
J Exp Med. 1971 Nov 1;134(5):1222-37. doi: 10.1084/jem.134.5.1222.
The segregation of the canine DL-A leukocyte group antigen(s) b, c, d, e, f, g, h, k, l, and m has been traced in 141 consecutive matings in the Cooperstown Colony of beagles. All of the leukocyte antigen(s) were regularly transmitted en bloc from parent to offspring, with no instance of independent segregation. A total of 23 haplotypes, including six different DL-A antigen patterns (gl, bkhfm, bkcd, e, be, fgl) was observed. 31 different DL-A phenotypes were observed in a population of 100 mongrel dogs. A number of statistically significant positive and negative associations between individual DL-A antigenic components occurred in this population. The results support the concept of the DL-A system as a complex immunogenetic system governed by a single region (or locus) of an autosomal pair of chromosomes. Studies of skin, kidney, heart, and liver allografts in the Cooperstown Colony indicated that the longest allograft survivals occur under genetically and serologically defined conditions of donor-recipient DL-A compatibility. Skin and renal allografts generally behaved in parallel fashion, while cardiac allografts survived for longer periods of time (MST = 47.1 days) than kidneys (MST = 28.1 days) or skin (MST = 25.1 days) under conditions of DL-A identity. Heart transplants were rejected at a more rapid rate than kidney, however, in DL-A-incompatible donor-recipient combinations. Liver transplants were accorded the longest survival time (MST = 76.2 days) under conditions of DL-A identity, but were rejected at a rapid rate (MST = 5 days) in DL-A-incompatible nonlittermate donor-recipient pairs. The results provide further evidence that the DL-A system is the principal system of histocompatibility in the canine species. The differences in survival of different organs under similar conditions of donor-recipient DL-A compatibility suggest, however, the existence of a number of unknown variables which may also be capable of significantly affecting allograft behavior.
在库珀斯敦比格犬繁殖群体的141次连续交配中，对犬类DL - A白细胞群抗原b、c、d、e、f、g、h、k、l和m的分离情况进行了追踪。所有白细胞抗原均以整体形式从亲代规律地传递给子代，未出现独立分离的情况。共观察到23种单倍型，包括六种不同的DL - A抗原模式（gl、bkhfm、bkcd、e、be、fgl）。在100只杂种犬群体中观察到31种不同的DL - A表型。在该群体中，个体DL - A抗原成分之间出现了一些具有统计学意义的正相关和负相关。这些结果支持了DL - A系统是由常染色体对的单个区域（或位点）控制的复杂免疫遗传系统这一概念。对库珀斯敦繁殖群体中的皮肤、肾脏、心脏和肝脏同种异体移植的研究表明，在供体 - 受体DL - A相容性的遗传和血清学定义条件下，同种异体移植存活时间最长。皮肤和肾脏同种异体移植的表现通常相似，而在DL - A相同的条件下，心脏同种异体移植的存活时间（平均存活时间 = 47.1天）比肾脏（平均存活时间 = 28.1天）或皮肤（平均存活时间 = 25.1天）更长。然而，在DL - A不相容的供体 - 受体组合中，心脏移植的排斥速度比肾脏更快。在DL - A相同的条件下，肝脏移植的存活时间最长（平均存活时间 = 76.2天），但在DL - A不相容的非同窝供体 - 受体对中，排斥速度很快（平均存活时间 = 5天）。这些结果进一步证明DL - A系统是犬类物种主要的组织相容性系统。然而，在供体 - 受体DL - A相容性相似的条件下，不同器官存活情况的差异表明，存在一些未知变量，它们也可能显著影响同种异体移植的行为。
