Lefford M J
Immunology. 1971 Aug;21(2):369-81.
In mice infected with BCG the rate of development of resistance to was related, and the growth of BCG in the liver and spleen was inversely related, to the size of the infecting inoculum. The rate of elimination of BCG after the onset of immunity was independent of the infecting dose. The effect of dose on the growth of BCG was abolished by immunosuppressants, and was restored by certain categories of lymphoid cells. Spleen and thymus cells, but not bone marrow cells, were able to confer immunity on X-irradiated recipients. There was no evidence of co-operation between thymus and bone marrow cells. It is concluded that the inoculum effect in BCG infections has an immunological basis. With increasing doses of BCG there is progressive reduction of the latent period prior to the induction of immunity.
在感染卡介苗的小鼠中，对[未提及的某种病原体]的抵抗力发展速率与感染接种量的大小相关，而卡介苗在肝脏和脾脏中的生长与感染接种量大小呈负相关。免疫开始后卡介苗的清除速率与感染剂量无关。免疫抑制剂可消除剂量对卡介苗生长的影响，而某些类型的淋巴细胞可恢复这种影响。脾脏和胸腺细胞而非骨髓细胞能够赋予受X射线照射的受体免疫力。没有证据表明胸腺细胞和骨髓细胞之间存在协同作用。得出的结论是，卡介苗感染中的接种量效应具有免疫学基础。随着卡介苗剂量的增加，免疫诱导前的潜伏期逐渐缩短。
