33%氧化亚氮的镇痛强度：信号检测理论评估
Analgesic strength of 33 percent nitrous oxide: a signal detection theory evaluation.
作者信息
Chapman C R, Murphy T M, Butler S H
出版信息
Science. 1973 Mar 23;179(4079):1246-8. doi: 10.1126/science.179.4079.1246.
PMID:4689019
Abstract
Radiant heat stimulation was applied to volunteers and rating scale responses were obtained to assess the analgesic properties of 33 percent nitrous oxide. The methodology of signal detection theory was applied to the data to demonstrate that nitrous oxide reduces both sensitivity to pain and willingness to report pain. This method is superior to threshold estimation for the evaluation of analgesics.
摘要
对志愿者施加辐射热刺激，并获取评分量表反应以评估33%氧化亚氮的镇痛特性。将信号检测理论方法应用于数据，以证明氧化亚氮既降低了对疼痛的敏感性，也降低了报告疼痛的意愿。该方法在评估镇痛药方面优于阈值估计。
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