Sasajima K, Kawachi T, Matsukura N, Sano T, Sugimura T
J Cancer Res Clin Oncol. 1979 Jun 8;94(2):201-6. doi: 10.1007/BF00422498.
PNNG, the propyl derivative of MNNG, was administered to Wistar rats by a concentration of 59.5 micrograms/ml in the drinking water for 4, 8, and 12 months and the rats were killed in the 15th month. Intestinal metaplasia was induced in the glandular stomachs of 25%, 75%, and 83% of the rats treated with PNNG for 4, 8, and 12 months, respectively. Metaplastic glands were found in the pyloric region, especially near the pyloric ring. These glands contained goblet cells and columnar cells with striated borders. No tumors were found in the stomach of rats after 4-months treatment, but adenomas were found after 8-months treatment, and both adenomas and adenocarcinomas after 12-months treatment.
将N-甲基-N'-硝基-N-亚硝基胍（MNNG）的丙基衍生物N-丙基-N'-硝基-N-亚硝基胍（PNNG）以59.5微克/毫升的浓度加入饮水中，给Wistar大鼠饮用4个月、8个月和12个月，并在第15个月处死大鼠。分别用PNNG处理4个月、8个月和12个月的大鼠，其腺胃中肠化生的诱导率分别为25%、75%和83%。在幽门区域，尤其是靠近幽门环的部位发现了化生腺体。这些腺体含有杯状细胞和有纹状缘的柱状细胞。4个月治疗后大鼠胃中未发现肿瘤，但8个月治疗后发现腺瘤，12个月治疗后发现腺瘤和腺癌。
