石棉沉着病相关胃癌的风险评估：一例报告
Risk assessment of gastric cancer associated with asbestosis: a case report.
作者信息
Park Soo-Hong, Kang Dong-Mug, Koo Bon-Hak, Kim Young-Ki, Kim Jong-Eun
机构信息
Department of Occupational and Environmental Medicine, Pusan National University Yangsan Hospital, Yangsan, South Korea.
Department of Occupational and Environmental Medicine, Pusan National University Yangsan Hospital, Yangsan, South Korea ; Department of Preventive and Occupational Medicine, School of Medicine, Pusan National University, Pusan, South Korea ; Environmental Health Center of Asbestos, Pusan National University Yangsan Hospital, Yangsan, South Korea.
出版信息
Ann Occup Environ Med. 2015 Mar 13;27:9. doi: 10.1186/s40557-015-0061-4. eCollection 2015.
BACKGROUND
The International Agency for Research on Cancer classifies asbestos as belonging to Carcinogen Group 2A for gastric cancer. We herein report a case of gastric cancer associated with asbestosis and describe the work-related and risk assessments of asbestos exposure for gastric cancer.
CASE PRESENTATION
The 66-year-old male patient in our case worked in asbestos spinning factories. His level of cumulated asbestos fiber exposure was estimated to be 38.0-71.0 f-yr/cc. Thus, the Excess Life Cancer Risk for lung cancer associated with asbestos exposure was 9,648×10(-5), almost 9,600 times the value recommended by the United States of America Environmental Protection Agency (1 × 10(-5)). The relative risk of developing lung cancer for this patient was more than 25 f-yr/cc, a well-known criterion for doubling the risk of lung cancer.
CONCLUSION
The patient's exposure to high-dose asbestos was sufficient to increase his risk of gastric cancer because as the risk of lung cancer increased, the risk of gastric cancer was due to increase as well. Therefore, occupational asbestos fiber exposure might be associated with gastric cancer in this case.
背景
国际癌症研究机构将石棉列为胃癌的2A类致癌物。我们在此报告一例与石棉肺相关的胃癌病例，并描述与工作相关的石棉暴露情况以及对胃癌的风险评估。
病例介绍
我们病例中的66岁男性患者曾在石棉纺织厂工作。据估计，他累积的石棉纤维暴露水平为38.0 - 71.0 f-yr/cc。因此，与石棉暴露相关的肺癌超额终身癌症风险为9,648×10⁻⁵，几乎是美国环境保护局推荐值（1×10⁻⁵）的9,600倍。该患者患肺癌的相对风险超过25 f-yr/cc，这是一个众所周知的肺癌风险翻倍标准。
结论
该患者接触高剂量石棉足以增加其患胃癌的风险，因为随着肺癌风险增加，胃癌风险也会相应增加。因此，在该病例中职业性石棉纤维暴露可能与胃癌有关。
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