Marynick S P, Loriaux D L, Sherins R J, Pita J C, Lipsett M B
J Clin Endocrinol Metab. 1979 Sep;49(3):396-8. doi: 10.1210/jcem-49-3-396.
Testosterone (T) was given to normal men with and without the concomitant administration of the aromatase inhibitor, delta 1-testolactone (Teslac), to examine the role of peripheral aromatization of T in gonadotropin regulation. When T was administered alone by continuous iv infusion (15 mg/day for 4 days), serum T increased 3-fold (P less than 0.01) and estradiol (E) increased by 50% (P less than 0.01). These changes were associated with a 50% decrease in serum LH and FSH concentrations (P less than 0.01). When T was infused into men taking Teslac (2000 mg/day), serum T levels doubled (P less than 0.01), but E levels did not change (13.4 +/- 1.5 vs. 13.5 +/- 1.0 pg/ml; P = NS). This pattern of plasma steroids, increased T and unchanged E, was also associated with significantly decreased serum LH and FSH concentrations (14.5 +/- 0.4 vs. 8.0 + 0.4 mIU/ml and 9.9 +/- 2.5 vs. 5.8 +/- 0.1 mIU/ml, respectively; P less than 0.01). These data support the hypothesis that T or one of its metabolites can modulate LH and FSH secretion independently of peripheral aromatization to E.
对正常男性给予睾酮（T），同时给予或不给予芳香化酶抑制剂δ1-睾酮内酯（Teslac），以研究T的外周芳香化作用在促性腺激素调节中的作用。当单独通过持续静脉输注给予T（15毫克/天，共4天）时，血清T增加了3倍（P<0.01），雌二醇（E）增加了50%（P<0.01）。这些变化伴随着血清促黄体生成素（LH）和促卵泡生成素（FSH）浓度降低50%（P<0.01）。当将T输注到服用Teslac（2000毫克/天）的男性体内时，血清T水平翻倍（P<0.01），但E水平没有变化（13.4±1.5对13.5±1.0皮克/毫升；P=无显著性差异）。这种血浆类固醇模式，即T升高而E不变，也与血清LH和FSH浓度显著降低有关（分别为14.5±0.4对8.0±0.4毫国际单位/毫升和9.9±2.5对5.8±0.1毫国际单位/毫升；P<0.01）。这些数据支持了这样的假设，即T或其代谢产物之一可以独立于外周芳香化为E来调节LH和FSH的分泌。
