Nicholls A, Snaith M L, Scott J T
Br Med J. 1973 Feb 24;1(5851):449-51. doi: 10.1136/bmj.1.5851.449.
Uric acid clearance studies were carried out on a low-purine diet in 22 trans-sexual men before and during oestrogen therapy for this condition (stilboestrol in 21 cases, ethinyloestradiol in one). Plasma uric acid fell in 15 of the subjects and urinary uric acid rose in 17 of 20 subjects in whom satisfactory collections were obtained. These changes are significant and it is suggested that hormonal influences are responsible for the known age and sex differences in plasma uric acid.
对22名变性男性在低嘌呤饮食条件下进行了尿酸清除率研究，研究在针对该病症的雌激素治疗前及治疗期间进行（21例使用己烯雌酚，1例使用炔雌醇）。在获得满意尿液收集的20名受试者中，15名受试者的血浆尿酸下降，17名受试者的尿尿酸上升。这些变化具有显著性，提示激素影响是血浆尿酸已知的年龄和性别差异的原因。
