雌激素疗法对血浆和尿液尿酸水平的影响。
Effect of oestrogen therapy on plasma and urinary levels of uric acid.
作者信息
Nicholls A, Snaith M L, Scott J T
出版信息
Br Med J. 1973 Feb 24;1(5851):449-51. doi: 10.1136/bmj.1.5851.449.
Abstract
Uric acid clearance studies were carried out on a low-purine diet in 22 trans-sexual men before and during oestrogen therapy for this condition (stilboestrol in 21 cases, ethinyloestradiol in one). Plasma uric acid fell in 15 of the subjects and urinary uric acid rose in 17 of 20 subjects in whom satisfactory collections were obtained. These changes are significant and it is suggested that hormonal influences are responsible for the known age and sex differences in plasma uric acid.
摘要
对22名变性男性在低嘌呤饮食条件下进行了尿酸清除率研究，研究在针对该病症的雌激素治疗前及治疗期间进行（21例使用己烯雌酚，1例使用炔雌醇）。在获得满意尿液收集的20名受试者中，15名受试者的血浆尿酸下降，17名受试者的尿尿酸上升。这些变化具有显著性，提示激素影响是血浆尿酸已知的年龄和性别差异的原因。
相似文献
1
Effect of oestrogen therapy on plasma and urinary levels of uric acid.雌激素疗法对血浆和尿液尿酸水平的影响。
Br Med J. 1973 Feb 24;1(5851):449-51. doi: 10.1136/bmj.1.5851.449.
2
Effect of long-term administration of cross-sex hormone therapy on serum and urinary uric acid in transsexual persons.长期给予跨性别激素疗法对变性者血清和尿尿酸的影响。
J Clin Endocrinol Metab. 2008 Jun;93(6):2230-3. doi: 10.1210/jc.2007-2467. Epub 2008 Mar 18.
3
Effect of stilboestrol on levels of uric acid in plasma and urine.己烯雌酚对血浆和尿液中尿酸水平的影响。
Ann Rheum Dis. 1973 Jul;32(4):386-7. doi: 10.1136/ard.32.4.386.
4
Effect of purine-free low-malt liquor (happo-shu) on the plasma concentrations and urinary excretion of purine bases and uridine--comparison between purine-free and regular happo-shu.无嘌呤低麦芽酒（发泡酒）对嘌呤碱和尿苷的血浆浓度及尿排泄的影响——无嘌呤发泡酒与常规发泡酒的比较
Horm Metab Res. 2004 Apr;36(4):231-7. doi: 10.1055/s-2004-814453.
5
6
Uric acid excretion in healthy subjects: a nomogram to assess the mechanisms underlying purine metabolic disorders.健康受试者尿酸排泄：评估嘌呤代谢紊乱机制的列线图。
Metabolism. 2012 Apr;61(4):512-8. doi: 10.1016/j.metabol.2011.08.005. Epub 2011 Oct 14.
7
Purine metabolism in patients with gout: the role of lead.痛风患者的嘌呤代谢：铅的作用。
Nephron. 1997;75(3):327-35. doi: 10.1159/000189557.
8
Effect of exercise and beer on the plasma concentration and urinary excretion of purine bases.运动和啤酒对嘌呤碱血浆浓度及尿排泄的影响。
J Rheumatol. 2003 May;30(5):1036-42.
9
Effect of weight-loss on plasma and urinary levels of uric acid.体重减轻对血浆和尿液尿酸水平的影响。
Lancet. 1972 Dec 9;2(7789):1223-4. doi: 10.1016/s0140-6736(72)92271-4.
10
Oestrogen as a reticuloendothelial stimulant in patients with cancer.雌激素作为癌症患者的网状内皮系统刺激剂。
Br Med J. 1971 May 15;2(5758):367-70. doi: 10.1136/bmj.2.5758.367.
引用本文的文献
1
Increase in visceral adipose tissue and altered metabolic profile in transgender men but not in transgender women one year after starting gender-affirming hormonal therapy.开始性别确认激素治疗一年后，跨性别男性的内脏脂肪组织增加且代谢状况改变，而跨性别女性则不然。
Endocrine. 2025 Jun 10. doi: 10.1007/s12020-025-04310-y.
2
Assessing cross-national inequalities and predictive trends in gout burden: a global perspective (1990-2021).评估痛风负担的跨国不平等和预测趋势：全球视角（1990 - 2021年）
Front Med (Lausanne). 2025 Mar 27;12:1527716. doi: 10.3389/fmed.2025.1527716. eCollection 2025.
3
Correlations of serum uric acid, fibrinogen and homocysteine levels with carotid atherosclerosis in hypertensive patients.高血压患者血清尿酸、纤维蛋白原及同型半胱氨酸水平与颈动脉粥样硬化的相关性
Front Cardiovasc Med. 2025 Mar 3;12:1433107. doi: 10.3389/fcvm.2025.1433107. eCollection 2025.
4
Sex-based disparities in the association between uric acid levels and anxiety: a cross-sectional analysis of nationwide data in Korea.尿酸水平与焦虑之间关联的性别差异：韩国全国数据的横断面分析
BMC Psychiatry. 2025 Jan 23;25(1):69. doi: 10.1186/s12888-025-06474-3.
5
Systemic inflammation response index association with gout in hyperuricemic adults: NHANES 2007-2018.高尿酸血症成年人中全身炎症反应指数与痛风的关联：美国国家健康与营养检查调查（NHANES）2007 - 2018年数据
Front Med (Lausanne). 2025 Jan 7;11:1490655. doi: 10.3389/fmed.2024.1490655. eCollection 2024.
6
Metabolomics in Atrial Fibrillation: Unlocking Novel Biomarkers and Pathways for Diagnosis, Prognosis, and Personalized Treatment.心房颤动中的代谢组学：揭示用于诊断、预后和个性化治疗的新型生物标志物和途径。
J Clin Med. 2024 Dec 25;14(1):34. doi: 10.3390/jcm14010034.
7
A single-center's uric acid profile in girls with Turner syndrome.单中心特纳综合征女孩的尿酸情况
Front Endocrinol (Lausanne). 2024 Nov 22;15:1442166. doi: 10.3389/fendo.2024.1442166. eCollection 2024.
8
A cross-sectional study of the association between blood metal mixtures exposure and hyperuricemia.横断面研究血液金属混合物暴露与高尿酸血症的关系。
Clin Rheumatol. 2024 Dec;43(12):3889-3900. doi: 10.1007/s10067-024-07156-3. Epub 2024 Oct 28.
9
Phosphorus modifies the association between body mass index and uric acid: Results from NHANES 2007-2018.磷改变了体重指数与尿酸之间的关联：来自 NHANES 2007-2018 的结果。
PLoS One. 2024 Oct 10;19(10):e0306383. doi: 10.1371/journal.pone.0306383. eCollection 2024.
10
Serum Uric Acid and Hyperuricemia Associate with Coronary Artery Disease among Postmenopausal Women.绝经后女性血清尿酸及高尿酸血症与冠状动脉疾病相关。
Rev Cardiovasc Med. 2022 Jun 24;23(7):222. doi: 10.31083/j.rcm2307222. eCollection 2022 Jul.
本文引用的文献
1
The enzymatic spectrophotometric method for determination of uric acid.用于测定尿酸的酶促分光光度法。
J Lab Clin Med. 1959 Dec;54:903-13.
2
THE DISTRIBUTION OF SERUM URIC ACID VALUES IN A POPULATION UNSELECTED AS TO GOUT OR HYPERURICEMIA: TECUMSEH, MICHIGAN 1959-1960.未因痛风或高尿酸血症而进行选择的人群中血清尿酸值的分布情况：密歇根州蒂卡姆西，1959 - 1960年。
Am J Med. 1965 Aug;39:242-51. doi: 10.1016/0002-9343(65)90048-3.
3
ASSOCIATION OF HYPERURICAEMIA AND GOUT WITH HYPERPARATHYROIDISM.高尿酸血症和痛风与甲状旁腺功能亢进的关联。
Br Med J. 1964 Apr 25;1(5390):1070-3. doi: 10.1136/bmj.1.5390.1070.
4
Aldosterone excretion in feces of rats treated with estradiol.
Endocrinology. 1962 Oct;71:598-604. doi: 10.1210/endo-71-4-598.
5
A three-component system for regulation of renal excretion of uric acid in man.一种调节人体尿酸肾排泄的三组分系统。
Trans Assoc Am Physicians. 1961;74:353-65.
6
Hyperuricemia in hyperparathyroidism.甲状旁腺功能亢进症中的高尿酸血症。
N Engl J Med. 1961 Jul 20;265:112-5. doi: 10.1056/NEJM196107202650302.
7
Hyperuricemia in myxedema.黏液性水肿中的高尿酸血症。
J Clin Endocrinol Metab. 1960 Nov;20:1457-66. doi: 10.1210/jcem-20-11-1457.
8
The effects of stilboestrol on the renal activity of conscious dogs.己烯雌酚对清醒犬肾脏活动的影响。
J Physiol. 1959 Mar 3;145(2):225-40. doi: 10.1113/jphysiol.1959.sp006138.
9
[Acute gout in women].[女性急性痛风]
Rhumatologie. 1957 Nov-Dec(6):261-7.
10
Possible aldosteronism in stilboestrol-treated guinea pigs.己烯雌酚处理的豚鼠中可能存在醛固酮增多症。
Lancet. 1956 Dec 8;271(6954):1192-3. doi: 10.1016/s0140-6736(56)90059-9.
Zotero 插件