一种表面抗原吸附流感病毒疫苗在儿童中的反应原性和免疫原性。
Reactogenicity and immunogenicity of a surface-antigen-adsorbed influenza virus vaccine in children.
作者信息
Eastwood L M, Jennings R, Milner R D, Potter C W
出版信息
J Clin Pathol. 1979 Jun;32(6):534-7. doi: 10.1136/jcp.32.6.534.
Abstract
An influenza virus vaccine containing the purified surface haemagglutinin and neuraminidase antigens of A/Victoria/75 and B/Hong Kong/73 viruses adsorbed to an aluminium hydroxide gel was assessed for reactogenicity and immunogenicity in children aged 4 to 11 years, since there is no influenza virus vaccine available for this age group. Significant serum haemagglutination-inhibiting antibody responses to the A/Victoria/75 and B/Hong Kong/73 haemagglutinin antigens present in the vaccine were observed in 47% and 35%, respectively, of the children vaccinated, with a single dose. The vaccine induced no significant local or systemic reactions.
摘要
一种含有吸附于氢氧化铝凝胶上的A/维多利亚/75和B/香港/73病毒纯化表面血凝素和神经氨酸酶抗原的流感病毒疫苗，在4至11岁儿童中进行了反应原性和免疫原性评估，因为该年龄组尚无流感病毒疫苗。接种单剂疫苗的儿童中，分别有47%和35%对疫苗中存在的A/维多利亚/75和B/香港/73血凝素抗原产生了显著的血清血凝抑制抗体反应。该疫苗未引起明显的局部或全身反应。
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