志愿者对灭活流感病毒疫苗的反应。
Responses of volunteers to inactivated influenza virus vaccines.
作者信息
Jennings R, Potter C W, Massey P M, Duerden B I, Martin J, Bevan A M
出版信息
J Hyg (Lond). 1981 Feb;86(1):1-16. doi: 10.1017/s0022172400068698.
Abstract
Three different types of bivalent influenza virus vaccine, a whole virus, an aqueous-surface-antigen vaccine and an adsorbed-surface-antigen vaccine were tested at three dosage levels in volunteers primed with respect to only one of the haemagglutinin antigens present in the vaccines. The local and systemic reactions to all three vaccine types were mild in nature and, following first immunization, the aqueous-surface-antigen vaccine was the least reactogenic. The serum haemagglutination-inhibiting antibody response to the A/Victoria/75 component of the vaccines to which the volunteer population was primed, was greatest following immunization with the aqueous-surface-antigen vaccine; the greatest antibody response to the A/New Jersey/76 component of the vaccines was observed following immunization with whole virus vaccine.
摘要
三种不同类型的二价流感病毒疫苗，即全病毒疫苗、水性表面抗原疫苗和吸附表面抗原疫苗，在仅针对疫苗中存在的一种血凝素抗原进行过免疫的志愿者中，以三种剂量水平进行了测试。所有三种疫苗类型引起的局部和全身反应性质均较轻，首次免疫后，水性表面抗原疫苗的反应原性最低。对于志愿者群体已针对其进行免疫的疫苗的A/维多利亚/75成分，接种水性表面抗原疫苗后血清血凝抑制抗体反应最强；接种全病毒疫苗后，观察到对疫苗的A/新泽西/76成分的抗体反应最强。
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