Pennington C R, Baqir Y A, Ross P E, Murison J, Bouchier I A
J Clin Pathol. 1979 Jun;32(6):565-6. doi: 10.1136/jcp.32.6.565.
The application of a sensitive gas liquid chromatography (GLC) assay has enabled patients in different diagnostic groups to be differentiated on the basis of the ratio of the primary bile acids, cholic: chenodeoxycholic acid. Because this method is unsuitable for a routine clinical laboratory, the primary bile acid ratio (PBR) is determined by radioimmunoassay techniques (RIA), and the results were compared with GLC analysis. RIA provided comparable results in control subjects and patients with large-duct obstruction, but significantly higher PBR values were found in cirrhotic subjects.
一种灵敏的气液色谱法（GLC）的应用能够根据初级胆汁酸（胆酸：鹅去氧胆酸）的比例区分不同诊断组的患者。由于该方法不适用于常规临床实验室，故采用放射免疫测定技术（RIA）测定初级胆汁酸比例（PBR），并将结果与GLC分析进行比较。在对照组和大导管梗阻患者中，RIA得出了可比的结果，但在肝硬化患者中发现PBR值显著更高。
