Pennington C R, Ross P E, Bateson M C, Bouchier I A
J Clin Pathol. 1978 Jan;31(1):58-62. doi: 10.1136/jcp.31.1.58.
Individual serum bile acids were analysed by an improved gas liquid chromatography method in 12 patients with primary hyperlipidaemia. Total serum bile acid concentrations were raised in 10 subjects. Ursodeoxycholic acid was found in all 12 patients. It was present in significantly greater concentrations, accounted for a greater proportion of the total serum bile acids, and occurred more frequently than in patients with various forms of hepatobiliary disease. Patients with hyperlipidaemia had proportionately less deoxycholic acid than controls but more than patients with liver disease. There was proportionately less chenodeoxycholic acid in patients with hypercholesterolaemia, in whom the primary bile acid ratio was raised.
采用改良的气液色谱法对12例原发性高脂血症患者的个体血清胆汁酸进行了分析。10名受试者的血清总胆汁酸浓度升高。在所有12例患者中均发现了熊去氧胆酸。其浓度显著更高，在血清总胆汁酸中所占比例更大，且比各种肝胆疾病患者出现的频率更高。高脂血症患者的脱氧胆酸比例比对照组少，但比肝病患者多。高胆固醇血症患者的鹅去氧胆酸比例相对较少，其初级胆汁酸比例升高。
