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Characterization of an irritant 4-deoxyphorbol diester from Euphorbia tirucalli.

作者信息

Kinghorn A D

出版信息

J Nat Prod. 1979 Jan-Feb;42(1):112-5. doi: 10.1021/np50001a006.

DOI:10.1021/np50001a006
PMID:469552
Abstract

Latex of Euphorbia tirucalli, collected in Colombia, yielded 12-O-2Z-4E-octadienoyl-4-deoxyphorbol-13-acetate (1), which exhibited an irritant potency equivalent to that of the standard irritant, phorbol-12-tetradecanoate-13-acetate, in a mouse ear test system. The unsaturated 4-deoxyphorbol diesters recently reported in E. tirucalli grown in South Africa were not observed in the present study.

摘要

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