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来自绿玉树乳汁的新型高刺激性大戟因子

New highly irritant euphorbia factors from latex of Euphorbia tirucalli L.

作者信息

Fürstenberger G, Hecker E

出版信息

Experientia. 1977 Aug 15;33(8):986-8. doi: 10.1007/BF01945920.

DOI:10.1007/BF01945920
PMID:891836
Abstract

From the latex of Euphorbia tirucalli L. growing in Madagascar, 5 new euphorbia factors were isolated. They were characterized as 13-O-acetyl-12-O-acylphorbol- and 12-O-acetyl-13-O-acylphorbol derivatives carrying homologous conjugated unsaturated fatty acids as acyl groups. Furthermore, 2 mixtures of homologous 3-O-acylingenol derivatives are obtained carrying the same type of unsaturated fatty acids. Due to their highly unsaturated acyl groups all Euphorbia factors or factor groups isolated are highly sensitive to autoxidation.

摘要

从生长在马达加斯加的绿玉树乳汁中分离出5种新的大戟因子。它们被鉴定为13 - O - 乙酰基 - 12 - O - 酰基佛波醇和12 - O - 乙酰基 - 13 - O - 酰基佛波醇衍生物,其酰基为具有同源共轭不饱和脂肪酸。此外,还获得了两种含有相同类型不饱和脂肪酸的同源3 - O - 酰基大戟醇衍生物混合物。由于其高度不饱和的酰基,所有分离出的大戟因子或因子组对自氧化都高度敏感。

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本文引用的文献

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Further new diterpene esters from the irritant and cocarcinogenic seed oil and latex of the caper spurge (Euphorbia lathyris L.).来自刺山柑大戟(Euphorbia lathyris L.)刺激性和致癌性种子油及乳胶中的更多新型二萜酯。
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Phorbolesters--the irritants and cocarcinogens of Croton Tiglium L.佛波酯——巴豆的刺激物和促癌物
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[On the active substances of croton oil. VII. Phorbol].[关于巴豆油的活性物质。VII. 佛波醇]
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