多巴胺对大鼠寒颤的影响。
The effect of dopamine on shivering in the rat.
作者信息
Marshall H W, Stoner H B
出版信息
J Physiol. 1979 Mar;288:393-9.
Abstract
- Dopamine (0.5--0.2 mumole) injected into a lateral cerebral ventricle inhibited shivering and lowered core temperature in rats at an ambient temperature of 0--5 degrees C. 2. These effects were inhibited by the dopamine antagonist, pimozide, and imitated by the dopamine agonists, piribedil and apomorphine. 3. Pimozide itself had no effect on shivering. 4. It is concluded that while there are inhibitory dopamine receptors on the cold sensor--shivering pathway in the rat they are not concerned in the normal function of this pathway.
摘要
- 将多巴胺（0.5 - 0.2微摩尔）注入大鼠侧脑室，在0 - 5摄氏度的环境温度下可抑制寒战并降低核心体温。2. 这些作用被多巴胺拮抗剂匹莫齐特抑制，而被多巴胺激动剂吡贝地尔和阿扑吗啡模拟。3. 匹莫齐特本身对寒战无作用。4. 得出的结论是，虽然在大鼠的冷感受器 - 寒战途径上存在抑制性多巴胺受体，但它们与该途径的正常功能无关。
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