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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Simmonds M A, Uretsky N J

Br J Pharmacol. 1970 Dec;40(4):630-8. doi: 10.1111/j.1476-5381.1970.tb10643.x.

Rats which had been pretreated with intraventricular injections of 6-hydroxydopamine (6-OHDA) to cause a selective depletion of brain noradrenaline (NA) to 20.7% of control brain NA and brain dopamine (DA) to 34.6% of control brain DA retained an unimpaired ability to regulate their body temperatures on exposure to heat or cold. This is discussed in relation to the possible role of brain NA in the central control of body temperature.2. Intraventricular injections of 6-OHDA in normal rats at room temperature caused an acute, dose dependent hypothermia of up to 4.5 degrees C which lasted for 4-5 hours. Depletion of brain NA and DA by prior treatment with 6-OHDA markedly reduced the hypothermic response to a subsequent dose of 6-OHDA. Selective depletion of brain NA without affecting brain DA did not reduce the response to 6-OHDA. The acute hypothermic response to 6-OHDA, may therefore, be related to a release of DA in the brain.

经脑室内注射6-羟基多巴胺（6-OHDA）预处理的大鼠，其脑去甲肾上腺素（NA）选择性耗竭至对照脑NA的20.7%，脑多巴胺（DA）耗竭至对照脑DA的34.6%，但在受热或受冷时仍保持调节体温的能力不受损害。本文就此探讨了脑NA在体温中枢控制中的可能作用。2. 在室温下给正常大鼠脑室内注射6-OHDA会引起急性、剂量依赖性体温降低，降幅可达4.5摄氏度，持续4至5小时。预先用6-OHDA处理使脑NA和DA耗竭，可显著降低对后续剂量6-OHDA的体温降低反应。选择性耗竭脑NA而不影响脑DA，不会降低对6-OHDA的反应。因此，对6-OHDA的急性体温降低反应可能与脑内DA的释放有关。

Simmonds M A, Uretsky N J

Br J Pharmacol. 1970 Dec;40(4):630-8. doi: 10.1111/j.1476-5381.1970.tb10643.x.

Rats which had been pretreated with intraventricular injections of 6-hydroxydopamine (6-OHDA) to cause a selective depletion of brain noradrenaline (NA) to 20.7% of control brain NA and brain dopamine (DA) to 34.6% of control brain DA retained an unimpaired ability to regulate their body temperatures on exposure to heat or cold. This is discussed in relation to the possible role of brain NA in the central control of body temperature.2. Intraventricular injections of 6-OHDA in normal rats at room temperature caused an acute, dose dependent hypothermia of up to 4.5 degrees C which lasted for 4-5 hours. Depletion of brain NA and DA by prior treatment with 6-OHDA markedly reduced the hypothermic response to a subsequent dose of 6-OHDA. Selective depletion of brain NA without affecting brain DA did not reduce the response to 6-OHDA. The acute hypothermic response to 6-OHDA, may therefore, be related to a release of DA in the brain.

经脑室内注射6-羟基多巴胺（6-OHDA）预处理的大鼠，其脑去甲肾上腺素（NA）选择性耗竭至对照脑NA的20.7%，脑多巴胺（DA）耗竭至对照脑DA的34.6%，但在受热或受冷时仍保持调节体温的能力不受损害。本文就此探讨了脑NA在体温中枢控制中的可能作用。2. 在室温下给正常大鼠脑室内注射6-OHDA会引起急性、剂量依赖性体温降低，降幅可达4.5摄氏度，持续4至5小时。预先用6-OHDA处理使脑NA和DA耗竭，可显著降低对后续剂量6-OHDA的体温降低反应。选择性耗竭脑NA而不影响脑DA，不会降低对6-OHDA的反应。因此，对6-OHDA的急性体温降低反应可能与脑内DA的释放有关。