6-羟基多巴胺对大鼠体温的中枢作用。
Central effects of 6-hydroxydopamine on the body temperature of the rat.
作者信息
Simmonds M A, Uretsky N J
出版信息
Br J Pharmacol. 1970 Dec;40(4):630-8. doi: 10.1111/j.1476-5381.1970.tb10643.x.
Abstract
- Rats which had been pretreated with intraventricular injections of 6-hydroxydopamine (6-OHDA) to cause a selective depletion of brain noradrenaline (NA) to 20.7% of control brain NA and brain dopamine (DA) to 34.6% of control brain DA retained an unimpaired ability to regulate their body temperatures on exposure to heat or cold. This is discussed in relation to the possible role of brain NA in the central control of body temperature.2. Intraventricular injections of 6-OHDA in normal rats at room temperature caused an acute, dose dependent hypothermia of up to 4.5 degrees C which lasted for 4-5 hours. Depletion of brain NA and DA by prior treatment with 6-OHDA markedly reduced the hypothermic response to a subsequent dose of 6-OHDA. Selective depletion of brain NA without affecting brain DA did not reduce the response to 6-OHDA. The acute hypothermic response to 6-OHDA, may therefore, be related to a release of DA in the brain.
摘要
- 经脑室内注射6-羟基多巴胺（6-OHDA）预处理的大鼠，其脑去甲肾上腺素（NA）选择性耗竭至对照脑NA的20.7%，脑多巴胺（DA）耗竭至对照脑DA的34.6%，但在受热或受冷时仍保持调节体温的能力不受损害。本文就此探讨了脑NA在体温中枢控制中的可能作用。2. 在室温下给正常大鼠脑室内注射6-OHDA会引起急性、剂量依赖性体温降低，降幅可达4.5摄氏度，持续4至5小时。预先用6-OHDA处理使脑NA和DA耗竭，可显著降低对后续剂量6-OHDA的体温降低反应。选择性耗竭脑NA而不影响脑DA，不会降低对6-OHDA的反应。因此，对6-OHDA的急性体温降低反应可能与脑内DA的释放有关。
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本文引用的文献
1
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Br J Pharmacol Chemother. 1967 Sep;31(1):152-61. doi: 10.1111/j.1476-5381.1967.tb01985.x.
2
Increased synthesis of norepinephrine and epinephrine in the intact rat during exercise and exposure to cold.在完整大鼠运动及暴露于寒冷环境期间，去甲肾上腺素和肾上腺素的合成增加。
J Pharmacol Exp Ther. 1966 Sep;153(3):440-7.
3
Effect of environmental temperature on the turnover of noradrenaline in hypothalamus and other areas of rat brain.环境温度对大鼠下丘脑及其他脑区去甲肾上腺素周转的影响。
J Physiol. 1969 Jul;203(1):199-210. doi: 10.1113/jphysiol.1969.sp008859.
4
The influence of ambient temperature on thermoregulatory responses to intraventricularly injected monoamines in sheep, goats and rabbits.环境温度对绵羊、山羊和兔子脑室内注射单胺类物质时体温调节反应的影响。
Experientia. 1969 Jun 15;25(6):608-9. doi: 10.1007/BF01896541.
5
Effects of 6-hydroxydopamine on noradrenaline-containing neurones in the rat brain.6-羟基多巴胺对大鼠脑中含去甲肾上腺素神经元的影响。
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6
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