Huszczuk A, Widdicombe J G
Acta Neurobiol Exp (Wars). 1973;33(1):391-9.
The level of integrated phrenic nerve activity (C3 root) has been studied under various forms of impairment of respiratory muscle function, such as paralysis (gallamine), pneumothorax and phrenectomy. Experiments were performed in two groups of rabbits artificially ventilated by means of the conventional respirator and the phrenic nerve driven respirator. It was found that both paralysis and bilateral pneumothorax were very strong stimuli exciting central inspiratory activity despite the constancy of ventilation. Under the same conditions phrenectomy caused only slight persistent excitation of the activity studied. It is worth noting that activity in the C3 root contralateral to the cut phrenic nerve trunk was as a rule more strongly stimulated. As artificial ventilation preceded by administration of gallamime is commonly applied in physiological experiments, the possibility of its effect on central respiratory activity will be discussed.
在多种呼吸肌功能受损形式下，如麻痹（加拉明）、气胸和膈神经切除术，研究了膈神经综合活动水平（C3神经根）。实验在两组兔子中进行，分别通过传统呼吸机和膈神经驱动呼吸机进行人工通气。结果发现，尽管通气保持恒定，但麻痹和双侧气胸都是强烈刺激中枢吸气活动的因素。在相同条件下，膈神经切除术仅引起所研究活动的轻微持续兴奋。值得注意的是，与切断的膈神经干对侧的C3神经根活动通常受到更强的刺激。由于在生理实验中通常采用加拉明给药后进行人工通气，因此将讨论其对中枢呼吸活动影响的可能性。
