Theriault R J, Longfield T H
Appl Microbiol. 1973 Apr;25(4):606-11. doi: 10.1128/am.25.4.606-611.1973.
Two hundred eighty-five fungi, including 100 basidiomycetes and 35 yeasts, 75 actinomycetes, and 40 bacteria were screened for their ability to convert 5-anilino-1,2,3,4-thiatriazole (AT) to 5-(p-hydroxyanilino)-1,2,3,4-thiatriazole (p-HT). Eleven cultures were found that formed p-HT, which was isolated and whose structure was determined. Aspergillus tamarii NRRL 3280 formed 8.6 g of p-HT/liter from 10 g of AT/liter (78.9% conversion) in shaken flasks and 4.57 g of p-HT/liter from 6 g of AT/liter (69.8% conversion) in 30-liter fermentors. Washed cells of A. tamarii NRRL 3280 also carried out this conversion. 5-(o-hydroxyanilino)-1,2,3,4-thiatriazole (o-HT) was identified as a second product formed by Aspergillus terreus NRRL 1960.
对285种真菌（包括100种担子菌和35种酵母）、75种放线菌和40种细菌进行了筛选，以检测它们将5-苯胺基-1,2,3,4-噻三唑（AT）转化为5-（对羟基苯胺基）-1,2,3,4-噻三唑（p-HT）的能力。发现有11种培养物能形成p-HT，对其进行了分离并确定了结构。黑曲霉NRRL 3280在摇瓶中从每升10克AT形成了每升8.6克p-HT（转化率78.9%），在30升发酵罐中从每升6克AT形成了每升4.57克p-HT（转化率69.8%）。黑曲霉NRRL 3280的洗涤细胞也能进行这种转化。5-（邻羟基苯胺基）-1,2,3,4-噻三唑（o-HT）被鉴定为土曲霉NRRL 1960形成的第二种产物。
